| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 2-Nov-09 | CURD JOHN G Officer | 5,000 | Direct | Purchase at $2.83 per share. | $14,150 | | 5-Oct-09 | FRAZIER HEALTHCARE VI, L.P. Beneficial Owner (10% or more) | 3,926,701 | Direct | Statement of Ownership | N/A | | 5-Oct-09 | FRAZIER HEALTHCARE VI, L.P. Beneficial Owner (10% or more) | 3,926,701 | Indirect | Statement of Ownership | N/A | | 5-Oct-09 | HEALTHCARE VENTURES VIII, L.P. Beneficial Owner (10% or more) | 1,570,680 | Indirect | Purchase | N/A | | 5-Oct-09 | SWEET DAVID E Beneficial Owner (10% or more) | 9,497 | Indirect | Purchase at $1.91 per share. | $18,139 | | 5-Oct-09 | JAEGER WILFRED E Director | 1,047,120 | Indirect | Purchase at $1.86 per share. | $1,947,643 | | 5-Oct-09 | SANDS GREGORY P Beneficial Owner (10% or more) | 24,679 | Indirect | Purchase at $1.91 per share. | $47,136 | | 5-Oct-09 | WHITE JAMES N Beneficial Owner (10% or more) | 37,619 | Indirect | Purchase at $1.91 per share. | $71,852 | | 5-Oct-09 | GAITHER JAMES C Beneficial Owner (10% or more) | 17,472 | Indirect | Purchase at $1.91 per share. | $33,371 | | 5-Oct-09 | YOUNGER WILLIAM H JR Beneficial Owner (10% or more) | 66,274 | Indirect | Purchase at $1.91 per share. | $126,583 | | 5-Oct-09 | SHEEHAN ANDREW T Beneficial Owner (10% or more) | 13,156 | Indirect | Purchase at $1.91 per share. | $25,127 | | 5-Oct-09 | SUTTER HILL VENTURES Beneficial Owner (10% or more) | 1,143,734 | Direct | Purchase at $1.91 per share. | $2,184,531 | | 5-Oct-09 | SUTTER HILL VENTURES Beneficial Owner (10% or more) | 1,143,734 | Direct | Purchase at $1.91 per share. | $2,184,531 | | 5-Oct-09 | CURD JOHN G Officer | 26,178 | Direct | Purchase at $1.86 per share. | $48,691 | | 5-Oct-09 | SELICK HAROLD E Officer | 52,356 | Direct | Purchase at $1.86 per share. | $97,382 | | 5-Oct-09 | BIRD JEFFREY W Director | 34,697 | Indirect | Purchase at $1.91 per share. | $66,271 | | 5-Oct-09 | BAKER G LEONARD JR Beneficial Owner (10% or more) | 40,566 | Indirect | Purchase at $1.91 per share. | $77,481 | | 5-Oct-09 | COXE TENCH Beneficial Owner (10% or more) | 151,896 | Indirect | Purchase at $1.91 per share. | $290,121 | | 5-Oct-09 | ANDERSON DAVID L Beneficial Owner (10% or more) | 27,558 | Indirect | Purchase at $1.91 per share. | $52,635 | | 5-Oct-09 | ALTA BIOPHARMA PARTNERS III LP Other | 22,012 | Indirect | Purchase at $1.91 per share. | $42,042 | | 5-Oct-09 | ALTA BIOPHARMA PARTNERS III LP Other | 239,768 | Direct | Purchase at $1.91 per share. | $457,956 | | 1-Oct-09 | CURD JOHN G Officer | 5,000 | Direct | Purchase at $1.83 per share. | $9,150 | | 1-Sep-09 | CURD JOHN G Officer | 5,000 | Direct | Purchase at $1.53 per share. | $7,650 | | 3-Aug-09 | CURD JOHN G Officer | 5,000 | Direct | Purchase at $1.59 per share. | $7,949 | | 1-Jul-09 | CURD JOHN G Officer | 5,000 | Direct | Purchase at $1.50 per share. | $7,500 | | 5-Jun-09 | SELICK HAROLD E Officer | 10,000 | Direct | Purchase at $1.48 per share. | $14,800 | | 3-Jun-09 | SELICK HAROLD E Officer | 10,000 | Direct | Purchase at $1.55 per share. | $15,500 | | 3-Jun-09 | CURD JOHN G Officer | 5,000 | Direct | Purchase at $1.49 per share. | $7,450 | | 1-Apr-09 | CURD JOHN G Officer | 5,000 | Direct | Purchase at $1.27 per share. | $6,350 | | 3-Mar-09 | CURD JOHN G Officer | 5,000 | Direct | Purchase at $1.07 per share. | $5,350 | | 26-Jan-09 | CURD JOHN G Officer | 5,000 | Direct | Purchase at $0.62 per share. | $3,100 | | 29-Oct-08 | CURD JOHN G Officer | 5,000 | Direct | Purchase at $0.45 per share. | $2,250 | | 29-Sep-08 | TANG KEVIN C Beneficial Owner (10% or more) | 4,716 | Direct | Statement of Ownership | N/A | | 29-Sep-08 | TANG KEVIN C Beneficial Owner (10% or more) | 1,400,988 | Indirect | Statement of Ownership | N/A | | 29-Aug-08 | HEALTHCARE VENTURES VIII, L.P. Beneficial Owner (10% or more) | 1,470,588 | Indirect | Statement of Ownership | N/A |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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