| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 16-Oct-08 | JEAN CHRISTOPHE Director | 3,333 | Direct | Disposition (Non Open Market) at $9 per share. | $29,997 | | 16-Oct-08 | WONG SUSAN Officer | 14,445 | Direct | Disposition (Non Open Market) at $9 per share. | $130,005 | | 16-Oct-08 | BANSAL AJAY Officer | 19,000 | Direct | Disposition (Non Open Market) at $9 per share. | $171,000 | | 16-Oct-08 | ROSENFIELD STEPHEN Officer | 38,500 | Direct | Disposition (Non Open Market) at $9 per share. | $346,500 | | 16-Oct-08 | GRETHLEIN ANDREW J Officer | 22,164 | Direct | Disposition (Non Open Market) at $9 per share. | $199,476 | | 16-Oct-08 | SCARLETT JOHN A Officer | 308,552 | Indirect | Disposition (Non Open Market) at $9 per share. | $2,776,968 | | 16-Oct-08 | SCARLETT JOHN A Officer | 645,852 | Direct | Disposition (Non Open Market) at $9 per share. | $5,812,668 | | 16-Oct-08 | EASTHAM KARIN Director | 13,333 | Direct | Disposition (Non Open Market) at $9 per share. | $119,997 | | 16-Oct-08 | BARKAS ALEXANDER E Director | 3,063,540 | Indirect | Disposition (Non Open Market) at $9 per share. | $27,571,860 | | 16-Oct-08 | BARKAS ALEXANDER E Director | 6,666 | Direct | Disposition (Non Open Market) at $9 per share. | $59,994 | | 16-Oct-08 | MAHONEY DAVID L Director | 3,333 | Direct | Disposition (Non Open Market) at $9 per share. | $29,997 | | 16-Oct-08 | KING RICHARD Officer | 24,000 | Direct | Disposition (Non Open Market) at $9 per share. | $216,000 | | 16-Oct-08 | VON STEIN THORSTEN Officer | 13,500 | Direct | Disposition (Non Open Market) at $9 per share. | $121,500 | | 16-Oct-08 | LESCHLY MARK Director | 3,004,951 | Indirect | Disposition (Non Open Market) at $9 per share. | $27,044,559 | | 16-Oct-08 | LESCHLY MARK Director | 3,333 | Direct | Disposition (Non Open Market) at $9 per share. | $29,997 | | 22-Jul-08 | IPSEN, S.A. Beneficial Owner (10% or more) | 15,723,601 | Direct | Acquisition (Non Open Market) at $7.41 - $47337000 per share. | N/A | | 22-Jul-08 | IPSEN, S.A. Beneficial Owner (10% or more) | 410,831 | Direct | Purchase at $8.92 per share. | $3,664,612 | | 20-May-08 | JEAN CHRISTOPHE Director | 3,333 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 20-May-08 | EASTHAM KARIN Director | 3,333 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 20-May-08 | BARKAS ALEXANDER E Director | 6,666 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 20-May-08 | MAHONEY DAVID L Director | 3,333 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 20-May-08 | LESCHLY MARK Director | 3,333 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 4-Apr-08 | SCARLETT JOHN A Officer | 33,500 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 25-Mar-08 | WONG SUSAN Officer | 6,750 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 25-Mar-08 | BANSAL AJAY Officer | 14,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 25-Mar-08 | ROSENFIELD STEPHEN Officer | 13,500 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 25-Mar-08 | GRETHLEIN ANDREW J Officer | 13,500 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 25-Mar-08 | KING RICHARD Officer | 21,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 25-Mar-08 | VON STEIN THORSTEN Officer | 13,500 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 25-Mar-08 | CLARK ROSS G Officer | 10,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 27-Feb-08 | HASNAIN FAHEEM Director | N/A | Direct | Statement of Ownership | N/A |
|
* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
|