| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 22-Oct-09 | ZORN PETER A Officer | 6,035 | Direct | Option Exercise at $5.55 per share. | $33,494 | | 22-Oct-09 | ZORN PETER A Officer | 6,035 | Direct | Sale at $20.64 per share. | $124,562 | | 21-Oct-09 | ZORN PETER A Officer | 91,898 | Direct | Option Exercise at $1.75 - $5.55 per share. | N/A | | 21-Oct-09 | ZORN PETER A Officer | 91,898 | Direct | Sale at $21 per share. | $1,929,858 | | 20-Oct-09 | ZORN PETER A Officer | 23,650 | Direct | Option Exercise at $1.75 - $5.63 per share. | N/A | | 20-Oct-09 | ZORN PETER A Officer | 23,650 | Direct | Sale at $21.40 per share. | $506,109 | | 20-Oct-09 | BRENNAN JEFFREY P Officer | 13,978 | Direct | Option Exercise at $1.75 per share. | $24,461 | | 20-Oct-09 | BRENNAN JEFFREY P Officer | 13,978 | Direct | Sale at $21.95 per share. | $306,817 | | 19-Oct-09 | ZORN PETER A Officer | 5,800 | Direct | Option Exercise at $5.10 per share. | $29,579 | | 19-Oct-09 | ZORN PETER A Officer | 5,800 | Direct | Sale at $22.68 per share. | $131,544 | | 19-Oct-09 | BRENNAN JEFFREY P Officer | 5,800 | Direct | Option Exercise at $1.75 per share. | $10,150 | | 19-Oct-09 | BRENNAN JEFFREY P Officer | 5,800 | Direct | Sale at $22.68 per share. | $131,544 | | 16-Oct-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 638,400 | Direct | Sale at $23.60 per share. | $15,066,240 | | 18-Sep-09 | DUNBAR GEOFFREY C Officer | 11,000 | Direct | Option Exercise at $1.75 per share. | $19,250 | | 18-Sep-09 | DUNBAR GEOFFREY C Officer | 11,000 | Direct | Sale at $17.19 per share. | $189,090 | | 16-Sep-09 | DUNBAR GEOFFREY C Officer | 9,050 | Direct | Option Exercise at $1.75 per share. | $15,837 | | 16-Sep-09 | DUNBAR GEOFFREY C Officer | 9,050 | Direct | Sale at $16.27 per share. | $147,243 | | 15-Sep-09 | DUNBAR GEOFFREY C Officer | 950 | Direct | Option Exercise at $1.75 per share. | $1,662 | | 15-Sep-09 | DUNBAR GEOFFREY C Officer | 950 | Direct | Sale at $16.01 per share. | $15,209 | | 8-Sep-09 | DEBETHIZY J DONALD Officer | 851 | Direct | Option Exercise at $1.75 per share. | $1,489 | | 8-Sep-09 | DEBETHIZY J DONALD Officer | 851 | Direct | Sale at $15 per share. | $12,765 | | 4-Sep-09 | MUSSO ALAN A Officer | 8,000 | Direct | Option Exercise at $1.75 per share. | $14,000 | | 4-Sep-09 | MUSSO ALAN A Officer | 8,000 | Direct | Sale at $15.07 per share. | $120,560 | | 4-Sep-09 | DUNBAR GEOFFREY C Officer | 10,000 | Direct | Option Exercise at $1.75 per share. | $17,500 | | 4-Sep-09 | DUNBAR GEOFFREY C Officer | 10,000 | Direct | Sale at $15.02 per share. | $150,200 | | 4-Sep-09 | DEBETHIZY J DONALD Officer | 11,149 | Direct | Option Exercise at $1.75 per share. | $19,510 | | 4-Sep-09 | DEBETHIZY J DONALD Officer | 11,149 | Direct | Sale at $15.02 per share. | $167,457 | | 4-Sep-09 | CALDWELL WILLIAM S Officer | 2,100 | Direct | Option Exercise at $1.75 per share. | $3,675 | | 4-Sep-09 | CALDWELL WILLIAM S Officer | 2,100 | Direct | Sale at $15.07 per share. | $31,647 | | 31-Aug-09 | CALDWELL WILLIAM S Officer | 13,955 | Direct | Option Exercise at $1.75 per share. | $24,421 | | 31-Aug-09 | CALDWELL WILLIAM S Officer | 13,955 | Direct | Sale at $14.54 per share. | $202,905 | | 31-Aug-09 | MUSSO ALAN A Officer | 5,400 | Direct | Option Exercise at $1.75 per share. | $9,450 | | 31-Aug-09 | MUSSO ALAN A Officer | 5,400 | Direct | Sale at $14.50 per share. | $78,300 | | 31-Aug-09 | DEBETHIZY J DONALD Officer | 9,400 | Direct | Option Exercise at $1.75 per share. | $16,450 | | 31-Aug-09 | DEBETHIZY J DONALD Officer | 9,400 | Direct | Sale at $14.54 per share. | $136,676 | | 28-Aug-09 | MUSSO ALAN A Officer | 600 | Direct | Option Exercise at $1.75 per share. | $1,050 | | 28-Aug-09 | MUSSO ALAN A Officer | 600 | Direct | Sale at $14.50 per share. | $8,700 | | 28-Aug-09 | DEBETHIZY J DONALD Officer | 600 | Direct | Option Exercise at $1.75 per share. | $1,050 | | 28-Aug-09 | DEBETHIZY J DONALD Officer | 600 | Direct | Sale at $14.50 per share. | $8,700 | | 28-Aug-09 | DUNBAR GEOFFREY C Officer | 7,900 | Direct | Option Exercise at $1.75 per share. | $13,825 | | 28-Aug-09 | DUNBAR GEOFFREY C Officer | 7,900 | Direct | Sale at $14.04 per share. | $110,916 | | 28-Aug-09 | CALDWELL WILLIAM S Officer | 5,400 | Direct | Option Exercise at $1.75 per share. | $9,450 | | 28-Aug-09 | CALDWELL WILLIAM S Officer | 5,400 | Direct | Sale at $14.08 - $14.5 per share. | $77,0002 | | 27-Aug-09 | DUNBAR GEOFFREY C Officer | 2,100 | Direct | Option Exercise at $1.75 per share. | $3,675 | | 27-Aug-09 | CALDWELL WILLIAM S Officer | 1,600 | Direct | Option Exercise at $1.75 per share. | $2,800 | | 27-Aug-09 | CALDWELL WILLIAM S Officer | 1,600 | Direct | Sale at $14 per share. | $22,400 | | 24-Aug-09 | MUSSO ALAN A Officer | 2,500 | Direct | Option Exercise at $1.75 per share. | $4,375 | | 24-Aug-09 | MUSSO ALAN A Officer | 2,500 | Direct | Sale at $13.55 per share. | $33,875 | | 24-Aug-09 | DEBETHIZY J DONALD Officer | 2,400 | Direct | Option Exercise at $1.75 per share. | $4,200 | | 24-Aug-09 | DEBETHIZY J DONALD Officer | 2,400 | Direct | Sale at $13.52 per share. | $32,448 | | 14-Aug-09 | MUSSO ALAN A Officer | 4,500 | Direct | Option Exercise at $1.75 per share. | $7,875 | | 14-Aug-09 | MUSSO ALAN A Officer | 4,500 | Direct | Sale at $13.51 per share. | $60,795 | | 14-Aug-09 | DEBETHIZY J DONALD Officer | 4,600 | Direct | Option Exercise at $1.75 per share. | $8,050 | | 14-Aug-09 | DEBETHIZY J DONALD Officer | 4,600 | Direct | Sale at $13.51 per share. | $62,146 | | 11-Aug-09 | CALDWELL WILLIAM S Officer | 6,780 | Direct | Option Exercise at $1.75 - $2.93 per share. | N/A | | 11-Aug-09 | CALDWELL WILLIAM S Officer | 6,780 | Direct | Sale at $12.69 per share. | $86,038 | | 10-Aug-09 | BRENNAN JEFFREY P Officer | 15,000 | Direct | Option Exercise at $1.75 per share. | $26,250 | | 10-Aug-09 | BRENNAN JEFFREY P Officer | 15,000 | Direct | Sale at $12.63 per share. | $189,450 | | 7-Aug-09 | MUSSO ALAN A Officer | 5,700 | Direct | Option Exercise at $1.75 per share. | $9,975 | | 7-Aug-09 | MUSSO ALAN A Officer | 5,700 | Direct | Sale at $12.02 - $12.04 per share. | $69,0002 | | 7-Aug-09 | DEBETHIZY J DONALD Officer | 5,700 | Direct | Option Exercise at $1.75 per share. | $9,975 | | 7-Aug-09 | DEBETHIZY J DONALD Officer | 5,700 | Direct | Sale at $12.02 - $12.04 per share. | $69,0002 | | 7-Aug-09 | CALDWELL WILLIAM S Officer | 771 | Direct | Option Exercise at $1.75 per share. | $1,349 | | 7-Aug-09 | CALDWELL WILLIAM S Officer | 771 | Direct | Sale at $12 - $12.04 per share. | $9,2672 | | 30-Jul-09 | CALDWELL WILLIAM S Officer | 636 | Direct | Option Exercise at $1.75 per share. | $1,113 | | 30-Jul-09 | CALDWELL WILLIAM S Officer | 636 | Direct | Sale at $12 per share. | $7,632 | | 29-Jul-09 | MUSSO ALAN A Officer | 5,263 | Direct | Option Exercise at $1.75 per share. | $9,210 | | 29-Jul-09 | MUSSO ALAN A Officer | 5,263 | Direct | Sale at $11.05 - $12 per share. | $61,0002 | | 29-Jul-09 | DEBETHIZY J DONALD Officer | 5,700 | Direct | Option Exercise at $1.75 per share. | $9,975 | | 29-Jul-09 | DEBETHIZY J DONALD Officer | 5,700 | Direct | Sale at $11.05 - $12 per share. | $66,0002 | | 29-Jul-09 | CALDWELL WILLIAM S Officer | 693 | Direct | Option Exercise at $1.75 per share. | $1,212 | | 29-Jul-09 | CALDWELL WILLIAM S Officer | 693 | Direct | Sale at $12 per share. | $8,316 | | 28-Jul-09 | MUSSO ALAN A Officer | 3,037 | Direct | Option Exercise at $1.75 per share. | $5,314 | | 28-Jul-09 | MUSSO ALAN A Officer | 3,037 | Direct | Sale at $11.02 per share. | $33,467 | | 28-Jul-09 | DEBETHIZY J DONALD Officer | 2,600 | Direct | Option Exercise at $1.75 per share. | $4,550 | | 28-Jul-09 | DEBETHIZY J DONALD Officer | 2,600 | Direct | Sale at $11.01 per share. | $28,626 | | 28-Jul-09 | BENCHERIF MEROUANE Officer | 41,213 | Direct | Option Exercise at $1.75 - $5.1 per share. | N/A | | 28-Jul-09 | BENCHERIF MEROUANE Officer | 41,213 | Direct | Sale at $10.39 per share. | $428,203 | | 27-Jul-09 | BENCHERIF MEROUANE Officer | 42,271 | Direct | Option Exercise at $1.75 - $5.55 per share. | N/A | | 27-Jul-09 | BENCHERIF MEROUANE Officer | 42,271 | Direct | Sale at $10.14 per share. | $428,627 | | 14-Jul-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 9,516 | Direct | Purchase at $2.99 per share. | $28,452 | | 13-Jul-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 2,200 | Direct | Purchase at $2.89 per share. | $6,358 | | 10-Jul-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 2,000 | Direct | Purchase at $2.79 per share. | $5,580 | | 9-Jul-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 21,500 | Direct | Purchase at $3.10 per share. | $66,650 | | 8-Jul-09 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 1,578,800 | Indirect | Statement of Ownership | N/A | | 17-Mar-09 | BROWN JULIA R Director | 7,500 | Direct | Purchase at $3.03 per share. | $22,725 | | 27-Aug-08 | DUNBAR GEOFFREY C Officer | 2,100 | Direct | Sale at $14 per share. | $29,400 | | 19-Aug-08 | DUNBAR GEOFFREY C Officer | 1,281 | Direct | Sale at $10 per share. | $12,810 | | 19-Aug-08 | DEBETHIZY J DONALD Officer | 1,700 | Direct | Option Exercise at $1.75 per share. | $2,975 | | 19-Aug-08 | DEBETHIZY J DONALD Officer | 1,700 | Direct | Sale at $10 per share. | $17,000 | | 18-Aug-08 | DUNBAR GEOFFREY C Officer | 700 | Direct | Sale at $10 per share. | $7,000 | | 18-Aug-08 | DEBETHIZY J DONALD Officer | 900 | Direct | Option Exercise at $1.75 per share. | $1,575 | | 18-Aug-08 | DEBETHIZY J DONALD Officer | 900 | Direct | Sale at $10.01 per share. | $9,009 | | 15-Aug-08 | MUSSO ALAN A Officer | 600 | Direct | Option Exercise at $1.75 per share. | $1,050 | | 15-Aug-08 | MUSSO ALAN A Officer | 600 | Direct | Sale at $10 per share. | $6,000 | | 15-Aug-08 | DUNBAR GEOFFREY C Officer | 100 | Direct | Sale at $10 per share. | $1,000 | | 15-Aug-08 | DEBETHIZY J DONALD Officer | 100 | Direct | Option Exercise at $1.75 per share. | $175 | | 15-Aug-08 | DEBETHIZY J DONALD Officer | 100 | Direct | Sale at $10 per share. | $1,000 | | 14-Aug-08 | MUSSO ALAN A Officer | 1,623 | Direct | Option Exercise at $1.75 per share. | $2,840 | | 14-Aug-08 | MUSSO ALAN A Officer | 1,623 | Direct | Sale at $10 per share. | $16,230 | | 14-Aug-08 | DUNBAR GEOFFREY C Officer | 1,473 | Direct | Sale at $10 per share. | $14,730 | | 14-Aug-08 | DEBETHIZY J DONALD Officer | 1,473 | Direct | Option Exercise at $1.75 per share. | $2,577 | | 14-Aug-08 | DEBETHIZY J DONALD Officer | 1,473 | Direct | Sale at $10 per share. | $14,730 | | 13-Aug-08 | MUSSO ALAN A Officer | 7,777 | Direct | Option Exercise at $1.75 per share. | $13,609 | | 13-Aug-08 | MUSSO ALAN A Officer | 7,777 | Direct | Sale at $10 per share. | $77,770 | | 13-Aug-08 | DUNBAR GEOFFREY C Officer | 2,149 | Direct | Sale at $10 per share. | $21,490 | | 13-Aug-08 | DEBETHIZY J DONALD Officer | 2,324 | Direct | Option Exercise at $1.75 per share. | $4,067 | | 13-Aug-08 | DEBETHIZY J DONALD Officer | 2,324 | Direct | Sale at $10 per share. | $23,240 | | 11-Aug-08 | DEBETHIZY J DONALD Officer | 100 | Direct | Option Exercise at $1.75 per share. | $175 | | 11-Aug-08 | DEBETHIZY J DONALD Officer | 100 | Direct | Sale at $10 per share. | $1,000 | | 8-Aug-08 | BRENNAN JEFFREY P Officer | 10,000 | Direct | Option Exercise at $1.75 per share. | $17,500 | | 8-Aug-08 | BRENNAN JEFFREY P Officer | 10,000 | Direct | Sale at $9.59 per share. | $95,900 | | 30-Jul-08 | DUNBAR GEOFFREY C Officer | 5,000 | Direct | Sale at $9.02 per share. | $45,100 | | 17-Jan-08 | TRAINOR III EUGENE A Beneficial Owner (10% or more) | 1,300,000 | Indirect | Acquisition (Non Open Market) at $7.07 per share. | $9,191,000 | | 17-Jan-08 | SANDELL SCOTT D Beneficial Owner (10% or more) | 1,300,000 | Indirect | Acquisition (Non Open Market) at $7.07 per share. | $9,191,000 | | 17-Jan-08 | NEWHALL CHARLES W III Beneficial Owner (10% or more) | 1,300,000 | Indirect | Acquisition (Non Open Market) at $7.07 per share. | $9,191,000 | | 17-Jan-08 | BARRIS PETER J Beneficial Owner (10% or more) | 1,300,000 | Indirect | Acquisition (Non Open Market) at $7.07 per share. | $9,191,000 | | 17-Jan-08 | NEA PARTNERS 10 L P Beneficial Owner (10% or more) | 1,300,000 | Indirect | Acquisition (Non Open Market) at $7.07 per share. | $9,191,000 | | 17-Jan-08 | PERRY MARK W Beneficial Owner (10% or more) | 1,300,000 | Indirect | Acquisition (Non Open Market) at $7.07 per share. | $9,191,000 | | 17-Jan-08 | BARRETT M JAMES Director | 1,300,000 | Indirect | Acquisition (Non Open Market) at $7.07 per share. | $9,191,000 | | 17-Jan-08 | NEW ENTERPRISE ASSOCIATES 10 L P Beneficial Owner (10% or more) | 1,300,000 | Direct | Acquisition (Non Open Market) at $7.07 per share. | $9,191,000 | | 17-Jan-08 | KRAMLICH C RICHARD Beneficial Owner (10% or more) | 1,300,000 | Indirect | Acquisition (Non Open Market) at $7.07 per share. | $9,191,000 |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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