| Date | Insider | Shares | Type | Transaction | Value* |
| 21-May-09 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1,063 | Indirect | Purchase at $6.08 - $6.1 per share. | $6,4732 |
| 21-May-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 38,120 | Indirect | Purchase at $6.08 - $6.1 per share. | $232,0002 |
| 21-May-09 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 86 | Indirect | Purchase at $6.08 - $6.1 per share. | $5232 |
| 21-May-09 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 24 | Indirect | Purchase at $6.08 - $6.1 per share. | $1462 |
| 19-May-09 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 2,256 | Indirect | Purchase at $5.98 - $6 per share. | $14,0002 |
| 19-May-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 80,991 | Indirect | Purchase at $5.98 - $6 per share. | $485,0002 |
| 19-May-09 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 183 | Indirect | Purchase at $5.98 - $6 per share. | $1,0962 |
| 19-May-09 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 52 | Indirect | Purchase at $5.98 - $6 per share. | $3112 |
| 18-May-09 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 2,455 | Indirect | Purchase at $5.84 - $6 per share. | $15,0002 |
| 18-May-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 88,121 | Indirect | Purchase at $5.84 - $6 per share. | $522,0002 |
| 18-May-09 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 199 | Indirect | Purchase at $5.84 - $6 per share. | $1,1782 |
| 18-May-09 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 56 | Indirect | Purchase at $5.84 - $6 per share. | $3312 |
| 13-May-09 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 12,279 | Indirect | Purchase at $5.45 - $5.46 per share. | $67,0002 |
| 13-May-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 440,623 | Indirect | Purchase at $5.45 - $5.46 per share. | $2,404,0002 |
| 13-May-09 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 996 | Indirect | Purchase at $5.45 - $5.46 per share. | $5,4332 |
| 13-May-09 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 279 | Indirect | Purchase at $5.45 - $5.46 per share. | $1,5212 |
| 11-May-09 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 2,695 | Indirect | Purchase at $5.86 per share. | $15,792 |
| 11-May-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 96,725 | Indirect | Purchase at $5.86 per share. | $566,808 |
| 11-May-09 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 219 | Indirect | Purchase at $5.86 per share. | $1,283 |
| 11-May-09 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 61 | Indirect | Purchase at $5.86 per share. | $357 |
| 8-May-09 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 3,669 | Indirect | Purchase at $5.92 per share. | $21,720 |
| 8-May-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 131,661 | Indirect | Purchase at $5.92 per share. | $779,433 |
| 8-May-09 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 298 | Indirect | Purchase at $5.92 per share. | $1,764 |
| 8-May-09 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 83 | Indirect | Purchase at $5.92 per share. | $491 |
| 7-May-09 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 6,088 | Indirect | Purchase at $5.72 - $5.73 per share. | $35,0002 |
| 7-May-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 218,471 | Indirect | Purchase at $5.72 - $5.73 per share. | $1,251,0002 |
| 7-May-09 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 494 | Indirect | Purchase at $5.72 - $5.73 per share. | $2,8282 |
| 7-May-09 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 138 | Indirect | Purchase at $5.72 - $5.73 per share. | $7902 |
| 6-May-09 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 157,067 | Indirect | Statement of Ownership | N/A |
| 6-May-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 6,039,675 | Indirect | Statement of Ownership | N/A |
| 6-May-09 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 81,950 | Indirect | Statement of Ownership | N/A |
| 6-May-09 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 105,105 | Indirect | Statement of Ownership | N/A |
| 6-May-09 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1,893,795 | Indirect | Statement of Ownership | N/A |
| 12-Mar-09 | SOLAND DANIEL B Officer | 30,000 | Direct | Purchase at $4.05 per share. | $121,500 |
| 27-Feb-09 | CLAYPOOL WILLIAM D MD Director | 20,000 | Direct | Purchase at $3.97 per share. | $79,400 |
| 27-Feb-09 | DOYLE THOMAS F Officer | 5,000 | Direct | Purchase at $3.94 per share. | $19,700 |
| 27-Feb-09 | MILANO VINCENT Officer | 2,300 | Direct | Purchase at $4.01 - $4.21 per share. | $9,4522 |
| 27-Feb-09 | GLASER ROBERT Director | 3,000 | Direct | Acquisition (Non Open Market) at $4.06 per share. | $12,179 |
| 26-Feb-09 | ROWLAND CHARLES A JR Officer | 16,000 | Direct | Purchase at $4.78 - $4.79 per share. | $77,0002 |
| 9-Jan-09 | DOYLE THOMAS F Officer | 22,500 | Direct | Option Exercise at $11.63 per share. | $261,675 |
| 9-Jan-09 | DOYLE THOMAS F Officer | 19,375 | Direct | Disposition (Non Open Market) at $13.50 per share. | $261,562 |
| 9-Jan-09 | MILANO VINCENT Officer | 22,500 | Direct | Option Exercise at $11.63 per share. | $261,675 |
| 9-Jan-09 | MILANO VINCENT Officer | 19,375 | Direct | Disposition (Non Open Market) at $13.50 per share. | $261,562 |
| 10-Nov-08 | DE ROSEN MICHEL Director | 7,747 | Direct | Sale at $12.30 per share. | $95,288 |
| 7-Nov-08 | DE ROSEN MICHEL Director | 292,930 | Direct | Sale at $12.15 per share. | $3,559,099 |
| 3-Nov-08 | ROWLAND CHARLES A JR Officer | 8,000 | Direct | Purchase at $12.77 per share. | $102,160 |
| 3-Nov-08 | DOUGHERTY MICHAEL R Director | 45,000 | Direct | Option Exercise at $3 - $3.42 per share. | $144,0002 |
| 3-Nov-08 | DOUGHERTY MICHAEL R Director | 45,000 | Direct | Sale at $12.76 per share. | $574,200 |
| 21-Oct-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 510 | Indirect | Acquisition (Non Open Market) at $2.74 per share. | $1,397 |
| 21-Oct-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 15,924 | Indirect | Acquisition (Non Open Market) at $2.74 per share. | $43,631 |
| 21-Oct-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 98 | Indirect | Acquisition (Non Open Market) at $2.74 per share. | $268 |
| 21-Oct-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 27 | Indirect | Acquisition (Non Open Market) at $2.74 per share. | $73 |
| 21-Oct-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 4,107 | Indirect | Acquisition (Non Open Market) at $2.74 per share. | $11,253 |
| 12-Sep-08 | BROOM COLIN MD Officer | 15,384 | Direct | Option Exercise at $3.14 per share. | $48,305 |
| 12-Sep-08 | BROOM COLIN MD Officer | 25,353 | Direct | Sale at $14.21 - $14.31 per share. | $362,0002 |
| 11-Sep-08 | MORRIS RICHARD STEVEN Officer | 2,200 | Direct | Sale at $14.29 - $14.31 per share. | $31,0002 |
| 29-May-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 697 | Indirect | Disposition (Non Open Market) at $0 per share. | N/A |
| 28-May-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 17,965 | Indirect | Disposition (Non Open Market) at $0 per share. | N/A |
| 14-Apr-08 | MORRIS RICHARD STEVEN Officer | 2,592 | Direct | Statement of Ownership | N/A |
| 17-Mar-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 181 | Indirect | Purchase at $8.14 per share. | $1,473 |
| 17-Mar-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 5,711 | Indirect | Purchase at $8.14 per share. | $46,487 |
| 17-Mar-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 15 | Indirect | Purchase at $8.14 per share. | $122 |
| 17-Mar-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1,927 | Indirect | Purchase at $8.14 per share. | $15,685 |
| 14-Mar-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 112 | Indirect | Purchase at $8.67 per share. | $971 |
| 14-Mar-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 3,536 | Indirect | Purchase at $8.67 per share. | $30,657 |
| 14-Mar-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 17 | Indirect | Purchase at $8.67 per share. | $147 |
| 14-Mar-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 9 | Indirect | Purchase at $8.67 per share. | $78 |
| 14-Mar-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1,326 | Indirect | Purchase at $8.67 per share. | $11,496 |
| 13-Mar-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1,591 | Indirect | Purchase at $8.69 per share. | $13,825 |
| 13-Mar-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 50,130 | Indirect | Purchase at $8.69 per share. | $435,629 |
| 13-Mar-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 237 | Indirect | Purchase at $8.69 per share. | $2,059 |
| 13-Mar-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 134 | Indirect | Purchase at $8.69 per share. | $1,164 |
| 13-Mar-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 18,792 | Indirect | Purchase at $8.69 per share. | $163,302 |
| 13-Feb-08 | DE ROSEN MICHEL Officer | 36,900 | Direct | Option Exercise at $2.71 per share. | $99,999 |
| 9-Jan-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 2,238 | Indirect | Purchase at $8.95 per share. | $20,030 |
| 9-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 70,449 | Indirect | Purchase at $8.95 per share. | $630,518 |
| 9-Jan-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 1,471 | Indirect | Purchase at $8.95 per share. | $13,165 |
| 9-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 192 | Indirect | Purchase at $8.95 per share. | $1,718 |
| 9-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 27,828 | Indirect | Purchase at $8.95 per share. | $249,060 |
| 8-Jan-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 3,274 | Indirect | Purchase at $8.76 per share. | $28,680 |
| 8-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 103,076 | Indirect | Purchase at $8.76 per share. | $902,945 |
| 8-Jan-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 2,153 | Indirect | Purchase at $8.76 per share. | $18,860 |
| 8-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 281 | Indirect | Purchase at $8.76 per share. | $2,461 |
| 8-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 40,716 | Indirect | Purchase at $8.76 per share. | $356,672 |