| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 4-Dec-09 | PRICE FREDRIC D Director | 1,666 | Direct | Option Exercise at $5.45 per share. | $9,079 | | 24-Sep-09 | QVT ASSOCIATES GP LLC Beneficial Owner (10% or more) | 800,000 | Indirect | Sale at $20.88 per share. | $16,704,000 | | 23-Sep-09 | QVT ASSOCIATES GP LLC Beneficial Owner (10% or more) | 10,000 | Indirect | Sale at $22.41 per share. | $224,100 | | 22-Sep-09 | QVT ASSOCIATES GP LLC Beneficial Owner (10% or more) | 100,000 | Indirect | Sale at $22.95 per share. | $2,295,000 | | 18-Sep-09 | OTTO MICHAEL J. Officer | 40,000 | Direct | Option Exercise at $3.87 per share. | $154,800 | | 18-Sep-09 | OTTO MICHAEL J. Officer | 40,000 | Direct | Sale at $21.90 - $21.97 per share. | $877,0002 | | 2-Sep-09 | PRICE FREDRIC D Director | 1,666 | Direct | Option Exercise at $5.45 per share. | $9,079 | | 1-Jun-09 | PRICE FREDRIC D Director | 21,666 | Direct | Option Exercise at $5.45 per share. | $118,079 | | 24-Mar-09 | WILLIAMSON ROBERT F III Director | 2,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 24-Mar-09 | CARNEY WILLIAM J Director | 2,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 24-Mar-09 | INOUYE MICHAEL K Director | 2,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 24-Mar-09 | PRICE FREDRIC D Director | 2,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 24-Mar-09 | CONRAD HERBERT J Director | 2,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 24-Mar-09 | BURRILL STEVEN Director | 2,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 24-Mar-09 | HAHN ELLIOT F Director | 2,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 27-Feb-09 | INOUYE MICHAEL K Director | 1,250 | Direct | Purchase at $10.07 - $10.11 per share. | $13,0002 | | 26-Feb-09 | INOUYE MICHAEL K Director | 1,250 | Direct | Purchase at $10.59 - $10.68 per share. | $13,0002 | | 25-Feb-09 | LUBETKIN PAUL Officer | 500 | Direct | Purchase at $10.14 - $10.65 per share. | $5,1972 | | 4-Feb-09 | QVT ASSOCIATES GP LLC Beneficial Owner (10% or more) | 3,703,274 | Indirect | Statement of Ownership | N/A | | 13-Nov-08 | ROGERS MICHAEL D. Officer | 16,672 | Direct | Option Exercise at $13.88 per share. | $231,407 | | 13-Nov-08 | ROGERS MICHAEL D. Officer | 2,901 | Direct | Sale at $18.62 - $18.75 per share. | $54,0002 | | 13-Nov-08 | ROGERS MICHAEL D. Officer | 13,771 | Direct | Sale at $18 - $18.59 per share. | $252,0002 | | 4-Nov-08 | ROGERS MICHAEL D. Officer | 500 | Direct | Option Exercise at $13.88 per share. | $6,940 | | 4-Nov-08 | ROGERS MICHAEL D. Officer | 500 | Direct | Sale at $18.02 - $18.25 per share. | $9,0672 | | 3-Nov-08 | ROGERS MICHAEL D. Officer | 1,578 | Direct | Option Exercise at $13.88 per share. | $21,902 | | 3-Nov-08 | ROGERS MICHAEL D. Officer | 1,578 | Direct | Sale at $18 per share. | $28,404 | | 24-Sep-08 | WILLIAMSON ROBERT F III Director | 2,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 24-Sep-08 | CARNEY WILLIAM J Director | 2,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 24-Sep-08 | INOUYE MICHAEL K Director | 2,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 24-Sep-08 | PRICE FREDRIC D Director | 2,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 24-Sep-08 | CONRAD HERBERT J Director | 2,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 24-Sep-08 | BURRILL STEVEN Director | 2,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 24-Sep-08 | HAHN ELLIOT F Director | 2,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 11-Aug-08 | OTTO MICHAEL J. Officer | 5,835 | Direct | Option Exercise at $3 per share. | $17,505 | | 11-Aug-08 | OTTO MICHAEL J. Officer | 5,835 | Direct | Sale at $21.06 - $21.82 per share. | $125,0002 | | 23-Jun-08 | EVNIN LUKE Other | 28,937 | Indirect | Sale at $19.90 - $20.1 per share. | $579,0002 | | 20-Jun-08 | BERREY M MICHELLE Officer | 2,976 | Direct | Option Exercise at $4.20 per share. | $12,499 | | 19-Jun-08 | BB BIOVENTURES L P Other | 155,800 | Indirect | Sale at $19.90 - $20 per share. | $3,108,0002 | | 19-Jun-08 | EVNIN LUKE Beneficial Owner (10% or more) | 155,800 | Indirect | Sale at $19.90 - $20 per share. | $3,108,0002 | | 17-Jun-08 | BB BIOVENTURES L P Beneficial Owner (10% or more) | 101,900 | Indirect | Sale at $20.15 - $20.25 per share. | $2,058,0002 | | 16-Jun-08 | GADICKE ANSBERT Beneficial Owner (10% or more) | 3,303 | Indirect | Sale at $19 - $19.38 per share. | $63,0002 | | 16-Jun-08 | GADICKE ANSBERT Beneficial Owner (10% or more) | 15,676 | Direct | Sale at $19 - $19.38 per share. | $301,0002 | | 16-Jun-08 | BB BIOVENTURES L P Beneficial Owner (10% or more) | 281,149 | Indirect | Sale at $20.05 - $20.46 per share. | $5,695,0002 | | 13-Jun-08 | GADICKE ANSBERT Beneficial Owner (10% or more) | 230 | Indirect | Sale at $19 per share. | $4,370 | | 13-Jun-08 | GADICKE ANSBERT Beneficial Owner (10% or more) | 1,091 | Direct | Sale at $19 per share. | $20,729 | | 10-Jun-08 | GADICKE ANSBERT Beneficial Owner (10% or more) | 901 | Indirect | Sale at $19 - $19.14 per share. | $17,0002 | | 10-Jun-08 | GADICKE ANSBERT Beneficial Owner (10% or more) | 4,274 | Direct | Sale at $19 - $19.14 per share. | $82,0002 | | 5-Jun-08 | GADICKE ANSBERT Beneficial Owner (10% or more) | 1,755 | Indirect | Sale at $19.15 per share. | $33,608 | | 5-Jun-08 | GADICKE ANSBERT Beneficial Owner (10% or more) | 8,328 | Direct | Sale at $19.15 per share. | $159,481 | | 27-May-08 | OTTO MICHAEL J. Officer | 81,264 | Direct | Option Exercise at $3 - $6 per share. | N/A | | 27-May-08 | OTTO MICHAEL J. Officer | 81,264 | Direct | Sale at $17.50 - $18.09 per share. | $1,446,0002 | | 19-May-08 | BERREY M MICHELLE Officer | 20,833 | Direct | Option Exercise at $4.20 per share. | $87,498 | | 19-May-08 | BERREY M MICHELLE Officer | 20,833 | Direct | Sale at $18 per share. | $374,994 | | 7-Apr-08 | OTTO MICHAEL J. Officer | 100 | Direct | Option Exercise at $6 per share. | $600 | | 7-Apr-08 | OTTO MICHAEL J. Officer | 100 | Direct | Sale at $20 per share. | $2,000 | | 4-Apr-08 | OTTO MICHAEL J. Officer | 400 | Direct | Option Exercise at $6 per share. | $2,400 | | 4-Apr-08 | OTTO MICHAEL J. Officer | 400 | Direct | Sale at $20 per share. | $8,000 | | 2-Apr-08 | SIMON NICHOLAS J III Beneficial Owner (10% or more) | 43 | Indirect | Sale at $20 per share. | $860 | | 2-Apr-08 | SIMON NICHOLAS J III Beneficial Owner (10% or more) | 5,074 | Direct | Sale at $20 per share. | $101,480 | | 2-Apr-08 | HENNER DENNIS Beneficial Owner (10% or more) | 745 | Indirect | Sale at $20 per share. | $14,900 | | 2-Apr-08 | HENNER DENNIS Beneficial Owner (10% or more) | 4,645 | Direct | Sale at $20 per share. | $92,900 | | 2-Apr-08 | OTTO MICHAEL J. Officer | 37,900 | Direct | Option Exercise at $2.55 - $6 per share. | N/A | | 2-Apr-08 | OTTO MICHAEL J. Officer | 37,900 | Direct | Sale at $20 - $20.05 per share. | $759,0002 | | 13-Mar-08 | LEUTZINGER KURT Officer | 1,000 | Direct | Purchase at $16.32 per share. | $16,320 | | 12-Mar-08 | LEUTZINGER KURT Officer | 4,000 | Direct | Purchase at $15.60 per share. | $62,400 | | 25-Feb-08 | CARNEY WILLIAM J Director | 26,667 | Direct | Option Exercise at $3 per share. | $80,001 | | 21-Feb-08 | GALAKATOS NICHOLAS Beneficial Owner (10% or more) | 304 | Indirect | Sale at $17.54 per share. | $5,332 | | 21-Feb-08 | GALAKATOS NICHOLAS Beneficial Owner (10% or more) | 10,632 | Direct | Sale at $17.54 per share. | $186,485 | | 8-Feb-08 | SIMON NICHOLAS J III Beneficial Owner (10% or more) | 6,874 | Indirect | Sale at $21.36 per share. | $146,828 | | 8-Feb-08 | BB BIOVENTURES L P Beneficial Owner (10% or more) | 27,925 | Indirect | Sale at $21.36 per share. | $596,478 | | 8-Feb-08 | MPM BIOVENTURES III-QP L.P. Beneficial Owner (10% or more) | 6,874 | Indirect | Sale at $21.36 per share. | $146,828 | | 7-Feb-08 | SIMON NICHOLAS J III Beneficial Owner (10% or more) | 17,450 | Indirect | Sale at $23.02 per share. | $401,699 | | 7-Feb-08 | BB BIOVENTURES L P Beneficial Owner (10% or more) | 36,664 | Indirect | Sale at $23.02 per share. | $844,005 | | 7-Feb-08 | MPM BIOVENTURES III-QP L.P. Beneficial Owner (10% or more) | 17,450 | Indirect | Sale at $23.02 per share. | $401,699 | | 4-Feb-08 | SIMON NICHOLAS J III Beneficial Owner (10% or more) | 100,673 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A | | 4-Feb-08 | SIMON NICHOLAS J III Beneficial Owner (10% or more) | 12,993 | Indirect | Sale at $23.86 per share. | $310,012 | | 4-Feb-08 | SIMON NICHOLAS J III Beneficial Owner (10% or more) | 713,912 | Indirect | Disposition (Non Open Market) at $0 per share. | N/A | | 4-Feb-08 | BB BIOVENTURES L P Beneficial Owner (10% or more) | 120,836 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A | | 4-Feb-08 | BB BIOVENTURES L P Beneficial Owner (10% or more) | 27,300 | Indirect | Sale at $23.86 per share. | $651,378 | | 4-Feb-08 | BB BIOVENTURES L P Beneficial Owner (10% or more) | 1,500,000 | Indirect | Disposition (Non Open Market) at $0 per share. | N/A | | 4-Feb-08 | MPM BIOVENTURES III-QP L.P. Beneficial Owner (10% or more) | 100,673 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A | | 4-Feb-08 | MPM BIOVENTURES III-QP L.P. Beneficial Owner (10% or more) | 12,993 | Indirect | Sale at $23.86 per share. | $310,012 | | 4-Feb-08 | MPM BIOVENTURES III-QP L.P. Beneficial Owner (10% or more) | 713,912 | Indirect | Disposition (Non Open Market) at $0 per share. | N/A |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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