| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 14-Oct-09 | BRISTOW MICHAEL R Officer | 7,394 | Direct | Option Exercise at $0.06 per share. | $443 | | 21-Jul-09 | LOWE DAVID GEORGE Director | 78,800 | Indirect | Sale at $3.94 per share. | $310,472 | | 20-Jul-09 | LOWE DAVID GEORGE Director | 102,000 | Indirect | Sale at $4.44 per share. | $452,880 | | 17-Jul-09 | LOWE DAVID GEORGE Director | 25,000 | Indirect | Sale at $4.19 per share. | $104,750 | | 16-Jun-09 | FALBERG KATHRYN E Officer | 21,000 | Direct | Sale at $3.58 - $3.68 per share. | $76,0002 | | 15-Jun-09 | LOWE DAVID GEORGE Director | 6,100 | Indirect | Sale at $3.90 per share. | $23,790 | | 15-Jun-09 | SKYLINE VENTURE PARTNERS QUALIFIED PURCHASER FUND Other | 6,100 | Direct | Sale at $3.90 per share. | $23,790 | | 12-Jun-09 | LOWE DAVID GEORGE Director | 3,800 | Indirect | Sale at $3.94 per share. | $14,972 | | 12-Jun-09 | SKYLINE VENTURE PARTNERS QUALIFIED PURCHASER FUND Other | 3,800 | Direct | Sale at $3.94 per share. | $14,972 | | 11-Jun-09 | LOWE DAVID GEORGE Director | 40,700 | Indirect | Sale at $3.84 per share. | $156,288 | | 11-Jun-09 | SKYLINE VENTURE PARTNERS QUALIFIED PURCHASER FUND Other | 40,700 | Direct | Sale at $3.84 per share. | $156,288 | | 10-Jun-09 | LOWE DAVID GEORGE Director | 36,000 | Indirect | Sale at $3.96 per share. | $142,560 | | 10-Jun-09 | SKYLINE VENTURE PARTNERS QUALIFIED PURCHASER FUND Other | 36,000 | Direct | Sale at $3.96 per share. | $142,560 | | 9-Jun-09 | LOWE DAVID GEORGE Director | 47,500 | Indirect | Sale at $3.99 per share. | $189,525 | | 9-Jun-09 | SKYLINE VENTURE PARTNERS QUALIFIED PURCHASER FUND Other | 47,500 | Direct | Sale at $3.99 per share. | $189,525 | | 8-Jun-09 | LOWE DAVID GEORGE Director | 65,708 | Indirect | Sale at $4.21 per share. | $276,630 | | 8-Jun-09 | SKYLINE VENTURE PARTNERS QUALIFIED PURCHASER FUND Other | 65,708 | Direct | Sale at $4.21 per share. | $276,630 | | 1-Jun-09 | LOWE DAVID GEORGE Director | 342,375 | Indirect | Disposition (Non Open Market) at $0 per share. | N/A | | 1-Jun-09 | SKYLINE VENTURE PARTNERS QUALIFIED PURCHASER FUND Beneficial Owner (10% or more) | 342,375 | Direct | Disposition (Non Open Market) at $0 per share. | N/A | | 6-Apr-09 | BOULDER VENTURES IV ANNEX LP Beneficial Owner (10% or more) | 549 | Indirect | Acquisition (Non Open Market) at $0 per share. | N/A | | 6-Apr-09 | BOULDER VENTURES IV ANNEX LP Beneficial Owner (10% or more) | 3,292 | Indirect | Disposition (Non Open Market) at $0 per share. | N/A | | 6-Apr-09 | BOULDER VENTURES IV ANNEX LP Beneficial Owner (10% or more) | 49,708 | Direct | Disposition (Non Open Market) at $0 per share. | N/A | | 23-Feb-09 | FALBERG KATHRYN E Officer | 21,000 | Direct | Statement of Ownership | N/A | | 27-Jan-09 | BOULDER VENTURES IV ANNEX LP Beneficial Owner (10% or more) | 48,007 | Indirect | Statement of Ownership | N/A | | 27-Jan-09 | BOULDER VENTURES IV ANNEX LP Beneficial Owner (10% or more) | 725,111 | Direct | Statement of Ownership | N/A | | 27-Jan-09 | ZABRISKIE JOHN L Director | 29,180 | Indirect | Statement of Ownership | N/A | | 27-Jan-09 | ST LAURENT RANDALL Officer | N/A | Direct | Statement of Ownership | N/A | | 27-Jan-09 | OZEROFF CHRISTOPHER DAVID Officer | 79,388 | Direct | Statement of Ownership | N/A | | 27-Jan-09 | LOWE DAVID GEORGE Director | 877,583 | Indirect | Statement of Ownership | N/A | | 27-Jan-09 | GRAIS LINDA S Director | 702,698 | Indirect | Statement of Ownership | N/A | | 27-Jan-09 | ATLAS VENTURE FUND VII L P Beneficial Owner (10% or more) | 1,402,163 | Direct | Statement of Ownership | N/A | | 27-Jan-09 | SKYLINE VENTURE PARTNERS QUALIFIED PURCHASER FUND Beneficial Owner (10% or more) | 877,583 | Direct | Statement of Ownership | N/A | | 27-Jan-09 | BREWER RICHARD B Officer | 83,490 | Direct | Statement of Ownership | N/A | | 27-Jan-09 | FREYTAG J WILLIAM Director | N/A | Direct | Statement of Ownership | N/A | | 27-Jan-09 | BRISTOW MICHAEL R Officer | 272,677 | Direct | Statement of Ownership | N/A | | 27-Jan-09 | FORMELA JEAN FRANCOIS Director | 1,402,163 | Indirect | Statement of Ownership | N/A |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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