| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 5-Jan-09 | TRUITT JOSEPH Officer | N/A | Direct | Statement of Ownership | N/A | | 18-Dec-08 | INVESTOR AB Beneficial Owner (10% or more) | 192,500 | Direct | Purchase at $0.95 - $1 per share. | $188,0002 | | 18-Dec-08 | INVESTOR AB Beneficial Owner (10% or more) | 275,000 | Indirect | Purchase at $0.95 - $1 per share. | $268,0002 | | 15-Dec-08 | LIOTTA DENNIS Director | N/A | Direct | Statement of Ownership | N/A | | 9-Dec-08 | INVESTOR AB Beneficial Owner (10% or more) | 35,000 | Direct | Purchase at $1 per share. | $35,000 | | 9-Dec-08 | INVESTOR AB Beneficial Owner (10% or more) | 50,000 | Indirect | Purchase at $1 per share. | $50,000 | | 8-Dec-08 | INVESTOR AB Beneficial Owner (10% or more) | 17,500 | Direct | Purchase at $1.01 per share. | $17,675 | | 8-Dec-08 | INVESTOR AB Beneficial Owner (10% or more) | 25,000 | Indirect | Purchase at $1.01 per share. | $25,250 | | 4-Dec-08 | INVESTOR GROWTH CAPITAL LTD Beneficial Owner (10% or more) | 1,783,862 | Direct | Statement of Ownership | N/A | | 4-Dec-08 | INVESTOR AB Beneficial Owner (10% or more) | 200,000 | Indirect | Purchase at $1 per share. | $200,000 | | 26-Nov-08 | INVESTOR AB Beneficial Owner (10% or more) | 24,700 | Indirect | Purchase at $1 per share. | $24,700 | | 8-Sep-08 | CLARUS LIFESCIENCES II, L.P. Beneficial Owner (10% or more) | 1,600 | Indirect | Purchase at $2.37 per share. | $3,792 | | 5-Sep-08 | CLARUS LIFESCIENCES II, L.P. Beneficial Owner (10% or more) | 3,054 | Indirect | Purchase at $2.19 per share. | $6,688 | | 5-Sep-08 | FENTON MARY KAY Officer | 3,125 | Direct | Option Exercise at $1.60 per share. | $5,000 | | 28-Aug-08 | OLEK ELIZABETH A Officer | 2,000 | Direct | Purchase at $2.29 - $2.46 per share. | $4,7502 | | 13-Aug-08 | CLARUS LIFESCIENCES II, L.P. Beneficial Owner (10% or more) | 5,163,689 | Direct | Statement of Ownership | N/A | | 12-Aug-08 | INVESTOR AB Beneficial Owner (10% or more) | 2,323,660 | Indirect | Statement of Ownership | N/A | | 12-Aug-08 | MOORIN JAY Beneficial Owner (10% or more) | 3,227,306 | Indirect | Statement of Ownership | N/A | | 31-Mar-08 | FRASHIER GARY E Director | 5,000 | Indirect | Statement of Ownership | N/A | | 6-Dec-07 | OLEK ELIZABETH A Officer | N/A | Direct | Statement of Ownership | N/A |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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