| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 23-Nov-09 | FEATHERINGILL WILLIAM W Director | 13,800 | Indirect | Sale at $9.56 per share. | $131,928 | | 20-Nov-09 | FEATHERINGILL WILLIAM W Director | 439,000 | Indirect | Sale at $9.66 per share. | $4,240,740 | | 26-Oct-09 | BABU YARLAGADDA S Officer | 6,400 | Direct | Automatic Sale at $10.85 per share. | $69,440 | | 21-Oct-09 | BABU YARLAGADDA S Officer | 200 | Direct | Automatic Sale at $10 per share. | $2,000 | | 20-Oct-09 | BABU YARLAGADDA S Officer | 3,400 | Direct | Automatic Sale at $10 per share. | $34,000 | | 14-Oct-09 | SHERIDAN WILLIAM P Officer | 6,000 | Direct | Automatic Sale at $8.92 per share. | $53,520 | | 23-Sep-09 | BABU YARLAGADDA S Officer | 20,000 | Direct | Sale at $9.14 per share. | $182,800 | | 23-Jul-09 | MILLS MIKE Officer | 1,500 | Direct | Option Exercise at $3.26 per share. | $4,890 | | 23-Jul-09 | MILLS MIKE Officer | 1,500 | Direct | Sale at $8.26 per share. | $12,390 | | 17-Jul-09 | MILLS MIKE Officer | 968 | Direct | Automatic Sale at $6 per share. | $5,808 | | 1-Jun-09 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 4,706 | Indirect | Sale at $3.86 - $3.89 per share. | $18,0002 | | 1-Jun-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 153,371 | Indirect | Sale at $3.86 - $3.89 per share. | $594,0002 | | 1-Jun-09 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 2,992 | Indirect | Sale at $3.86 - $3.89 per share. | $12,0002 | | 1-Jun-09 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 11,191 | Indirect | Sale at $3.86 - $3.89 per share. | $43,0002 | | 1-Jun-09 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 70,159 | Indirect | Sale at $3.86 - $3.89 per share. | $272,0002 | | 29-May-09 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 3,880 | Indirect | Sale at $4.12 - $4.3 per share. | $16,0002 | | 29-May-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 126,448 | Indirect | Sale at $4.12 - $4.3 per share. | $532,0002 | | 29-May-09 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 2,467 | Indirect | Sale at $4.12 - $4.3 per share. | $10,0002 | | 29-May-09 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 9,226 | Indirect | Sale at $4.12 - $4.3 per share. | $39,0002 | | 29-May-09 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 57,847 | Indirect | Sale at $4.12 - $4.3 per share. | $244,0002 | | 28-May-09 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 7,274 | Indirect | Sale at $4.45 - $4.5 per share. | $33,0002 | | 28-May-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 237,113 | Indirect | Sale at $4.45 - $4.5 per share. | $1,061,0002 | | 28-May-09 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 4,626 | Indirect | Sale at $4.45 - $4.5 per share. | $21,0002 | | 28-May-09 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 17,302 | Indirect | Sale at $4.45 - $4.5 per share. | $77,0002 | | 28-May-09 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 108,472 | Indirect | Sale at $4.45 - $4.5 per share. | $485,0002 | | 12-Mar-09 | ERCK STANLEY C Director | 40,000 | Direct | Purchase at $1.22 per share. | $48,800 | | 30-Jan-09 | SHERIDAN WILLIAM P Officer | 3,000 | Direct | Purchase at $1.62 per share. | $4,860 | | 30-Jan-09 | GRANT STUART Officer | 3,000 | Direct | Purchase at $1.62 per share. | $4,860 | | 30-Jan-09 | STONEHOUSE JON P Officer | 3,000 | Direct | Purchase at $1.62 per share. | $4,860 | | 1-Jan-09 | MILLS MIKE Officer | 798 | Direct | Statement of Ownership | N/A | | 23-Dec-08 | BABU YARLAGADDA S Officer | 57,650 | Direct | Statement of Ownership | N/A | | 1-Dec-08 | STONEHOUSE JON P Officer | 55,000 | Direct | Purchase at $1.48 per share. | $81,400 | | 24-Nov-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 201 | Indirect | Purchase at $0.98 per share. | $196 | | 24-Nov-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 7,401 | Indirect | Purchase at $0.98 per share. | $7,252 | | 24-Nov-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 49 | Indirect | Purchase at $0.98 per share. | $48 | | 24-Nov-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 2,339 | Indirect | Purchase at $0.98 per share. | $2,292 | | 24-Nov-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 10 | Indirect | Purchase at $0.98 per share. | $9 | | 21-Nov-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 848 | Indirect | Purchase at $0.91 per share. | $771 | | 21-Nov-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 31,071 | Indirect | Purchase at $0.91 per share. | $28,274 | | 21-Nov-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 207 | Indirect | Purchase at $0.91 per share. | $188 | | 21-Nov-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 9,831 | Indirect | Purchase at $0.91 per share. | $8,946 | | 21-Nov-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 43 | Indirect | Purchase at $0.91 per share. | $39 | | 20-Nov-08 | 14159 CAPITAL (GP), LLC Beneficial Owner (10% or more) | 8,278 | Indirect | Purchase at $1 per share. | $8,278 | | 20-Nov-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Beneficial Owner (10% or more) | 303,517 | Indirect | Purchase at $1 per share. | $303,517 | | 20-Nov-08 | BAKER / TISCH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 2,028 | Indirect | Purchase at $1 per share. | $2,028 | | 20-Nov-08 | BAKER BIOTECH CAPITAL (GP), LLC Beneficial Owner (10% or more) | 96,033 | Indirect | Purchase at $1 per share. | $96,033 | | 20-Nov-08 | BAKER BROS. CAPITAL (GP), LLC Beneficial Owner (10% or more) | 422 | Indirect | Purchase at $1 per share. | $422 | | 3-Nov-08 | STONEHOUSE JON P Officer | 25,000 | Direct | Purchase at $1.74 - $1.75 per share. | $44,0002 | | 12-Aug-08 | STONEHOUSE JON P Officer | 2,300 | Direct | Purchase at $3.10 per share. | $7,130 | | 11-Aug-08 | STONEHOUSE JON P Officer | 7,700 | Direct | Purchase at $2.95 per share. | $22,715 | | 4-Aug-08 | GRANT STUART Officer | 3,000 | Direct | Purchase at $2.82 per share. | $8,460 | | 4-Aug-08 | STONEHOUSE JON P Officer | 240 | Direct | Purchase at $2.82 per share. | $676 | | 31-Jul-08 | DARWIN MICHAEL A Officer | 1,709 | Direct | Purchase at $2.82 per share. | $4,819 | | 31-Jan-08 | STONEHOUSE JON P Officer | 3,000 | Direct | Purchase at $3.50 per share. | $10,500 | | 31-Jan-08 | DARWIN MICHAEL A Officer | 1,339 | Direct | Purchase at $3.50 per share. | $4,686 |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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