| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 26-Jan-09 | COLE JASON Officer | 2,633 | Direct | Automatic Sale at $0.63 per share. | $1,658 | | 26-Jan-09 | BORISY ALEXIS Officer | 5,256 | Direct | Automatic Sale at $0.63 per share. | $3,311 | | 26-Jan-09 | FORRESTER ROBERT Officer | 2,632 | Direct | Automatic Sale at $0.63 per share. | $1,658 | | 5-Dec-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 1,530,572 | Indirect | Purchase at $0.57 per share. | $872,426 | | 4-Dec-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 10,300 | Indirect | Purchase at $0.55 per share. | $5,665 | | 3-Dec-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 13,400 | Indirect | Purchase at $0.54 per share. | $7,236 | | 2-Dec-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 9,800 | Indirect | Purchase at $0.55 per share. | $5,390 | | 1-Dec-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 26,800 | Indirect | Purchase at $0.55 per share. | $14,740 | | 26-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 6,600 | Indirect | Purchase at $0.49 per share. | $3,234 | | 25-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 12,300 | Indirect | Purchase at $0.47 per share. | $5,781 | | 24-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 83,100 | Indirect | Purchase at $0.45 per share. | $37,395 | | 21-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 12,000 | Indirect | Purchase at $0.45 per share. | $5,400 | | 14-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 9,200 | Indirect | Purchase at $0.60 per share. | $5,520 | | 13-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 9,000 | Indirect | Purchase at $0.60 per share. | $5,400 | | 12-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 3,600 | Indirect | Purchase at $0.60 per share. | $2,160 | | 11-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 139,100 | Indirect | Purchase at $0.60 per share. | $83,460 | | 10-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 14,000 | Indirect | Purchase at $0.58 per share. | $8,119 | | 7-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 109,700 | Indirect | Purchase at $0.58 per share. | $63,625 | | 6-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 11,200 | Indirect | Purchase at $0.59 per share. | $6,608 | | 5-Nov-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 180,400 | Indirect | Purchase at $0.60 per share. | $108,240 | | 16-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 2,031,000 | Indirect | Purchase at $0.65 per share. | $1,320,150 | | 15-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 712,000 | Indirect | Purchase at $0.65 per share. | $462,800 | | 13-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 25,500 | Indirect | Purchase at $0.65 per share. | $16,575 | | 10-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 58,300 | Indirect | Purchase at $0.60 per share. | $34,980 | | 8-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 103,100 | Indirect | Purchase at $0.62 per share. | $63,922 | | 7-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 790,000 | Indirect | Purchase at $0.66 per share. | $521,400 | | 6-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 4,107,899 | Indirect | Statement of Ownership | N/A | | 6-Oct-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 2,429,000 | Direct | Statement of Ownership | N/A | | 24-Apr-08 | BAIRD LYNN G Officer | 1,588 | Direct | Disposition (Non Open Market) at $3.58 per share. | $5,685 | | 26-Jan-08 | GRAU DANIEL Officer | 15,875 | Direct | Disposition (Non Open Market) at $5.15 per share. | $81,756 | | 26-Jan-08 | BORISY ALEXIS Officer | 3,969 | Direct | Disposition (Non Open Market) at $5.15 per share. | $20,440 | | 26-Jan-08 | KEITH CURTIS T Officer | 2,372 | Direct | Disposition (Non Open Market) at $5.15 per share. | $12,215 | | 26-Jan-08 | FORRESTER ROBERT Officer | 1,985 | Direct | Disposition (Non Open Market) at $5.15 per share. | $10,222 | | 15-Jan-08 | COLE JASON Officer | 25,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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