| Date | Insider | Shares | Type | Transaction | Value* |
| 24-Sep-09 | 14159 CAPITAL (GP), LLC Director | 101,506 | Indirect | Acquisition (Non Open Market) at $6.75 per share. | $685,165 |
| 24-Sep-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 1,848,200 | Indirect | Acquisition (Non Open Market) at $6.75 per share. | $12,475,350 |
| 24-Sep-09 | BAKER / TISCH CAPITAL (GP), LLC Director | 50,294 | Indirect | Acquisition (Non Open Market) at $6.75 per share. | $339,484 |
| 9-Mar-09 | FRIEDMAN PAUL A Officer | 9,400 | Direct | Purchase at $2.10 per share. | $19,740 |
| 6-Mar-09 | FRIEDMAN PAUL A Officer | 10,600 | Direct | Purchase at $2.10 per share. | $22,260 |
| 5-Mar-09 | FRIEDMAN PAUL A Officer | 8,840 | Direct | Purchase at $2.20 per share. | $19,448 |
| 5-Mar-09 | 14159 CAPITAL (GP), LLC Director | 312 | Indirect | Purchase at $2.16 per share. | $673 |
| 5-Mar-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 11,232 | Indirect | Purchase at $2.16 per share. | $24,261 |
| 5-Mar-09 | BAKER / TISCH CAPITAL (GP), LLC Director | 64 | Indirect | Purchase at $2.16 per share. | $138 |
| 5-Mar-09 | BAKER BROS. CAPITAL (GP), LLC Director | 5 | Indirect | Purchase at $2.16 per share. | $10 |
| 5-Mar-09 | BAKER BIOTECH CAPITAL (GP), LLC Director | 1,248 | Indirect | Purchase at $2.16 per share. | $2,695 |
| 3-Mar-09 | FRIEDMAN PAUL A Officer | 11,160 | Direct | Purchase at $2.20 per share. | $24,552 |
| 3-Mar-09 | 14159 CAPITAL (GP), LLC Director | 264 | Indirect | Purchase at $2.14 per share. | $564 |
| 3-Mar-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 9,524 | Indirect | Purchase at $2.14 per share. | $20,381 |
| 3-Mar-09 | BAKER / TISCH CAPITAL (GP), LLC Director | 98 | Indirect | Purchase at $2.14 per share. | $209 |
| 3-Mar-09 | BAKER BROS. CAPITAL (GP), LLC Director | 5 | Indirect | Purchase at $2.14 per share. | $10 |
| 3-Mar-09 | BAKER BIOTECH CAPITAL (GP), LLC Director | 2,199 | Indirect | Purchase at $2.14 per share. | $4,705 |
| 2-Mar-09 | 14159 CAPITAL (GP), LLC Director | 927 | Indirect | Purchase at $2.14 - $2.17 per share. | $1,9972 |
| 2-Mar-09 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 33,364 | Indirect | Purchase at $2.14 - $2.17 per share. | $72,0002 |
| 2-Mar-09 | BAKER / TISCH CAPITAL (GP), LLC Director | 343 | Indirect | Purchase at $2.14 - $2.17 per share. | $7392 |
| 2-Mar-09 | BAKER BROS. CAPITAL (GP), LLC Director | 17 | Indirect | Purchase at $2.14 - $2.17 per share. | $362 |
| 2-Mar-09 | BAKER BIOTECH CAPITAL (GP), LLC Director | 7,701 | Indirect | Purchase at $2.14 - $2.17 per share. | $17,0002 |
| 27-Jan-09 | FRIEDMAN STEVEN M. Officer | 54,389 | Direct | Statement of Ownership | N/A |
| 19-Dec-08 | 14159 CAPITAL (GP), LLC Director | 7,772 | Indirect | Purchase at $3.60 - $3.62 per share. | $28,0002 |
| 19-Dec-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 284,546 | Indirect | Purchase at $3.60 - $3.62 per share. | $1,027,0002 |
| 19-Dec-08 | BAKER / TISCH CAPITAL (GP), LLC Director | 1,927 | Indirect | Purchase at $3.60 - $3.62 per share. | $6,9562 |
| 19-Dec-08 | BAKER BROS. CAPITAL (GP), LLC Director | 1,454 | Indirect | Purchase at $3.60 - $3.62 per share. | $5,2482 |
| 19-Dec-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | 89,241 | Indirect | Purchase at $3.60 - $3.62 per share. | $322,0002 |
| 18-Dec-08 | 14159 CAPITAL (GP), LLC Director | 6,252 | Indirect | Purchase at $3.56 - $3.6 per share. | $22,0002 |
| 18-Dec-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 228,972 | Indirect | Purchase at $3.56 - $3.6 per share. | $820,0002 |
| 18-Dec-08 | BAKER / TISCH CAPITAL (GP), LLC Director | 1,628 | Indirect | Purchase at $3.56 - $3.6 per share. | $5,8282 |
| 18-Dec-08 | BAKER BROS. CAPITAL (GP), LLC Director | 133 | Indirect | Purchase at $3.56 - $3.6 per share. | $4762 |
| 18-Dec-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | 68,463 | Indirect | Purchase at $3.56 - $3.6 per share. | $245,0002 |
| 17-Dec-08 | 14159 CAPITAL (GP), LLC Director | 6,061 | Indirect | Purchase at $3.15 - $3.33 per share. | $20,0002 |
| 17-Dec-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 221,814 | Indirect | Purchase at $3.15 - $3.33 per share. | $719,0002 |
| 17-Dec-08 | BAKER / TISCH CAPITAL (GP), LLC Director | 1,501 | Indirect | Purchase at $3.15 - $3.33 per share. | $4,8632 |
| 17-Dec-08 | BAKER BROS. CAPITAL (GP), LLC Director | 309 | Indirect | Purchase at $3.15 - $3.33 per share. | $1,0012 |
| 17-Dec-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | 69,566 | Indirect | Purchase at $3.15 - $3.33 per share. | $225,0002 |
| 21-Nov-08 | METCALF BRIAN W Officer | 5,000 | Direct | Purchase at $2.17 - $2.2 per share. | $11,0002 |
| 20-Nov-08 | CHARDONNET LAURENT Other | 8,000 | Direct | Purchase at $2.70 - $2.71 per share. | $22,0002 |
| 20-Nov-08 | FRIEDMAN PAUL A Officer | 13,000 | Direct | Purchase at $2.55 per share. | $33,150 |
| 20-Nov-08 | SCHRECK PATRICIA A Officer | 2,500 | Direct | Purchase at $2.44 per share. | $6,100 |
| 20-Nov-08 | HASTINGS DAVID C Officer | 4,000 | Direct | Purchase at $2.36 per share. | $9,440 |
| 15-Oct-08 | FRIEDMAN PAUL A Officer | 5,300 | Direct | Purchase at $4.60 per share. | $24,379 |
| 14-Oct-08 | FRIEDMAN PAUL A Officer | 4,700 | Direct | Purchase at $5.34 - $5.35 per share. | $25,0002 |
| 31-Jul-08 | 14159 CAPITAL (GP), LLC Director | 27,724 | Indirect | Purchase at $9 per share. | $249,516 |
| 31-Jul-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 864,092 | Indirect | Purchase at $9 per share. | $7,776,828 |
| 31-Jul-08 | BAKER / TISCH CAPITAL (GP), LLC Director | 4,997 | Indirect | Purchase at $9 per share. | $44,973 |
| 31-Jul-08 | BAKER BROS. CAPITAL (GP), LLC Director | 1,539 | Indirect | Purchase at $9 per share. | $13,851 |
| 31-Jul-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | 201,648 | Indirect | Purchase at $9 per share. | $1,814,832 |
| 22-Jan-08 | 14159 CAPITAL (GP), LLC Director | 7 | Indirect | Purchase at $10.62 per share. | $74 |
| 22-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 223 | Indirect | Purchase at $10.62 per share. | $2,368 |
| 22-Jan-08 | BAKER / TISCH CAPITAL (GP), LLC Director | 4 | Indirect | Purchase at $10.62 per share. | $42 |
| 22-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Director | 1 | Indirect | Purchase at $10.62 per share. | $10 |
| 22-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | 65 | Indirect | Purchase at $10.62 per share. | $690 |
| 14-Jan-08 | 14159 CAPITAL (GP), LLC Director | 1,101 | Indirect | Purchase at $10.99 per share. | $12,099 |
| 14-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 34,621 | Indirect | Purchase at $10.99 per share. | $380,484 |
| 14-Jan-08 | BAKER / TISCH CAPITAL (GP), LLC Director | 723 | Indirect | Purchase at $10.99 per share. | $7,945 |
| 14-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Director | 94 | Indirect | Purchase at $10.99 per share. | $1,033 |
| 14-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | 13,675 | Indirect | Purchase at $10.99 per share. | $150,288 |
| 11-Jan-08 | 14159 CAPITAL (GP), LLC Director | 973 | Indirect | Purchase at $10.94 per share. | $10,644 |
| 11-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 30,682 | Indirect | Purchase at $10.94 per share. | $335,661 |
| 11-Jan-08 | BAKER / TISCH CAPITAL (GP), LLC Director | 641 | Indirect | Purchase at $10.94 per share. | $7,012 |
| 11-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Director | 84 | Indirect | Purchase at $10.94 per share. | $918 |
| 11-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | 12,120 | Indirect | Purchase at $10.94 per share. | $132,592 |
| 10-Jan-08 | 14159 CAPITAL (GP), LLC Director | 40 | Indirect | Purchase at $11.01 per share. | $440 |
| 10-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 1,241 | Indirect | Purchase at $11.01 per share. | $13,663 |
| 10-Jan-08 | BAKER / TISCH CAPITAL (GP), LLC Director | 26 | Indirect | Purchase at $11.01 per share. | $286 |
| 10-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Director | 3 | Indirect | Purchase at $11.01 per share. | $33 |
| 10-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | 490 | Indirect | Purchase at $11.01 per share. | $5,394 |
| 9-Jan-08 | 14159 CAPITAL (GP), LLC Director | 2,878 | Indirect | Purchase at $10.94 per share. | $31,485 |
| 9-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 90,591 | Indirect | Purchase at $10.94 per share. | $991,065 |
| 9-Jan-08 | BAKER / TISCH CAPITAL (GP), LLC Director | 1,892 | Indirect | Purchase at $10.94 per share. | $20,698 |
| 9-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Director | 247 | Indirect | Purchase at $10.94 per share. | $2,702 |
| 9-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | 35,783 | Indirect | Purchase at $10.94 per share. | $391,466 |
| 8-Jan-08 | 14159 CAPITAL (GP), LLC Director | 15,337 | Indirect | Purchase at $10 - $10.89 per share. | $160,0002 |
| 8-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 482,798 | Indirect | Purchase at $10 - $10.89 per share. | $5,043,0002 |
| 8-Jan-08 | BAKER / TISCH CAPITAL (GP), LLC Director | 10,080 | Indirect | Purchase at $10 - $10.89 per share. | $105,0002 |
| 8-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Director | 1,318 | Indirect | Purchase at $10 - $10.89 per share. | $14,0002 |
| 8-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | 190,709 | Indirect | Purchase at $10 - $10.89 per share. | $1,992,0002 |
| 7-Jan-08 | 14159 CAPITAL (GP), LLC Director | 6,744 | Indirect | Purchase at $9.48 per share. | $63,933 |
| 7-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 212,282 | Indirect | Purchase at $9.48 per share. | $2,012,433 |
| 7-Jan-08 | BAKER / TISCH CAPITAL (GP), LLC Director | 4,432 | Indirect | Purchase at $9.48 per share. | $42,015 |
| 7-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Director | 579 | Indirect | Purchase at $9.48 per share. | $5,488 |
| 7-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | 83,853 | Indirect | Purchase at $9.48 per share. | $794,926 |
| 4-Jan-08 | 14159 CAPITAL (GP), LLC Director | 9,492 | Indirect | Purchase at $9.47 per share. | $89,889 |
| 4-Jan-08 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 298,752 | Indirect | Purchase at $9.47 per share. | $2,829,181 |
| 4-Jan-08 | BAKER / TISCH CAPITAL (GP), LLC Director | 6,237 | Indirect | Purchase at $9.47 per share. | $59,064 |
| 4-Jan-08 | BAKER BROS. CAPITAL (GP), LLC Director | 815 | Indirect | Purchase at $9.47 per share. | $7,718 |
| 4-Jan-08 | BAKER BIOTECH CAPITAL (GP), LLC Director | 118,009 | Indirect | Purchase at $9.47 per share. | $1,117,545 |
| 19-Dec-07 | 14159 CAPITAL (GP), LLC Director | 2,834 | Indirect | Purchase at $10.61 per share. | $30,068 |
| 19-Dec-07 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 89,198 | Indirect | Purchase at $10.61 per share. | $946,390 |
| 19-Dec-07 | BAKER / TISCH CAPITAL (GP), LLC Director | 1,862 | Indirect | Purchase at $10.61 per share. | $19,755 |
| 19-Dec-07 | BAKER BROS. CAPITAL (GP), LLC Director | 243 | Indirect | Purchase at $10.61 per share. | $2,578 |
| 19-Dec-07 | BAKER BIOTECH CAPITAL (GP), LLC Director | 35,234 | Indirect | Purchase at $10.61 per share. | $373,832 |
| 18-Dec-07 | 14159 CAPITAL (GP), LLC Director | 1,710 | Indirect | Purchase at $10.58 per share. | $18,091 |
| 18-Dec-07 | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC Director | 53,824 | Indirect | Purchase at $10.58 per share. | $569,457 |
| 18-Dec-07 | BAKER / TISCH CAPITAL (GP), LLC Director | 1,124 | Indirect | Purchase at $10.58 per share. | $11,891 |
| 18-Dec-07 | BAKER BROS. CAPITAL (GP), LLC Director | 147 | Indirect | Purchase at $10.58 per share. | $1,555 |
| 18-Dec-07 | BAKER BIOTECH CAPITAL (GP), LLC Director | 21,261 | Indirect | Purchase at $10.58 per share. | $224,941 |