| INSIDER TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Type | Transaction | Value* | | 26-Jan-09 | NADER FRANCOIS Officer | 20,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 22-Sep-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 283,200 | Indirect | Sale at $8.72 per share. | $2,469,504 | | 19-Sep-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 191,600 | Indirect | Sale at $8.55 per share. | $1,638,180 | | 17-Apr-08 | NADER FRANCOIS Officer | 21,534 | Direct | Option Exercise at $0 per share. | N/A | | 17-Apr-08 | NADER FRANCOIS Officer | 7,623 | Direct | Disposition (Non Open Market) at $3.60 per share. | $27,442 | | 19-Mar-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 3,400 | Indirect | Purchase at $3.90 per share. | $13,260 | | 17-Mar-08 | NADER FRANCOIS Officer | 50,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 17-Mar-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 45,500 | Indirect | Purchase at $3.80 per share. | $172,900 | | 17-Mar-08 | COLES N ANTHONY Officer | 62,572 | Direct | Disposition (Non Open Market) at $3.85 per share. | $240,902 | | 17-Mar-08 | COLES N ANTHONY Officer | 135,000 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 14-Mar-08 | COLES N ANTHONY Officer | 76,336 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A | | 14-Mar-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 100,000 | Indirect | Purchase at $3.84 per share. | $384,000 | | 13-Mar-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 8,300 | Indirect | Purchase at $3.77 per share. | $31,291 | | 12-Mar-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 38,600 | Indirect | Purchase at $3.82 per share. | $147,452 | | 11-Mar-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 53,900 | Indirect | Purchase at $3.71 per share. | $199,969 | | 10-Mar-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 126,000 | Indirect | Purchase at $3.73 per share. | $469,980 | | 7-Mar-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 146,100 | Indirect | Purchase at $3.81 per share. | $556,641 | | 6-Mar-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 4,336,115 | Indirect | Statement of Ownership | N/A | | 6-Mar-08 | BVF PARTNERS L P/IL Beneficial Owner (10% or more) | 2,559,000 | Direct | Statement of Ownership | N/A | | 11-Jan-08 | COLES N ANTHONY Officer | 9,302 | Direct | Disposition (Non Open Market) at $3.87 per share. | $35,998 | | 11-Jan-08 | COLES N ANTHONY Officer | 25,839 | Direct | Acquisition (Non Open Market) at $0 per share. | N/A |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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