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    Isis Pharmaceuticals, Inc. (ISIS)

    -NasdaqGS
    63.65 Up 4.16(6.99%) Dec 26, 4:00PM EST
    |After Hours : 63.74 Up 0.09 (0.14%) Dec 26, 7:55PM EST
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    Key StatisticsGet Key Statistics for:
    Data provided by Capital IQ, except where noted.
    Valuation Measures 
    Market Cap (intraday)5:7.52B
    Enterprise Value (Dec 28, 2014)3:6.90B
    Trailing P/E (ttm, intraday):N/A
    Forward P/E (fye Dec 31, 2015)1:N/A
    PEG Ratio (5 yr expected)1:-4.10
    Price/Sales (ttm):40.97
    Price/Book (mrq):20.36
    Enterprise Value/Revenue (ttm)3:40.24
    Enterprise Value/EBITDA (ttm)6:-112.02
    Financial Highlights 
    Fiscal Year
    Fiscal Year Ends:Dec 31
    Most Recent Quarter (mrq):Sep 30, 2014
    Profitability
    Profit Margin (ttm):-54.98%
    Operating Margin (ttm):-41.41%
    Management Effectiveness
    Return on Assets (ttm):-5.30%
    Return on Equity (ttm):-25.28%
    Income Statement
    Revenue (ttm):171.55M
    Revenue Per Share (ttm):1.46
    Qtrly Revenue Growth (yoy):86.80%
    Gross Profit (ttm):147.28M
    EBITDA (ttm)6:-61.63M
    Net Income Avl to Common (ttm):-94.31M
    Diluted EPS (ttm):-0.81
    Qtrly Earnings Growth (yoy):N/A
    Balance Sheet
    Total Cash (mrq):640.43M
    Total Cash Per Share (mrq):5.42
    Total Debt (mrq):234.76M
    Total Debt/Equity (mrq):68.09
    Current Ratio (mrq):6.35
    Book Value Per Share (mrq):2.92
    Cash Flow Statement
    Operating Cash Flow (ttm):-78.89M
    Levered Free Cash Flow (ttm):-32.18M
    View Financials
    Income Statement - Balance Sheet - Cash Flow

    Trading Information 
    Stock Price History
    Beta:1.63
    52-Week Change3:59.36%
    S&P500 52-Week Change3:13.45%
    52-Week High (Dec 19, 2014)3:67.12
    52-Week Low (May 9, 2014)3:22.25
    50-Day Moving Average3:54.54
    200-Day Moving Average3:41.15
    Share Statistics
    Avg Vol (3 month)3:2,626,440
    Avg Vol (10 day)3:4,519,310
    Shares Outstanding5:118.14M
    Float:117.29M
    % Held by Insiders1:0.79%
    % Held by Institutions1:88.80%
    Shares Short (as of Nov 28, 2014)3:14.65M
    Short Ratio (as of Nov 28, 2014)3:6.20
    Short % of Float (as of Nov 28, 2014)3:14.70%
    Shares Short (prior month)3:14.96M
    Dividends & Splits
    Forward Annual Dividend Rate4:N/A
    Forward Annual Dividend Yield4:N/A
    Trailing Annual Dividend Yield3:N/A
    Trailing Annual Dividend Yield3:N/A
    5 Year Average Dividend Yield4:N/A
    Payout Ratio4:N/A
    Dividend Date3:N/A
    Ex-Dividend Date4:N/A
    Last Split Factor (new per old)2:N/A
    Last Split Date3:N/A

    See Key Statistics Help for definitions of terms used.
    Abbreviation Guide: K = Thousands; M = Millions; B = Billions
    mrq = Most Recent Quarter (as of Sep 30, 2014)
    ttm = Trailing Twelve Months (as of Sep 30, 2014)
    yoy = Year Over Year (as of Sep 30, 2014)
    lfy = Last Fiscal Year (as of Dec 31, 2013)
    fye = Fiscal Year Ending
    1 Data provided by Thomson Reuters
    2 Data provided by EDGAR Online
    3 Data derived from multiple sources or calculated by Yahoo! Finance
    4 Data provided by Morningstar, Inc.
    5 Shares outstanding is taken from the most recently filed quarterly or annual report and Market Cap is calculated using shares outstanding.
    6 EBITDA is calculated by Capital IQ using methodology that may differ from that used by a company in its reporting

    Currency in USD.