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    Isis Pharmaceuticals, Inc. (ISIS)

    54.93 Up 1.76(3.31%) Jul 31, 4:00PM EDT
    |After Hours : 54.45 Down 0.48 (0.87%) Jul 31, 6:09PM EDT
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    Key StatisticsGet Key Statistics for:
    Data provided by Capital IQ, except where noted.
    Valuation Measures 
    Market Cap (intraday)5:6.58B
    Enterprise Value (Aug 1, 2015)3:6.04B
    Trailing P/E (ttm, intraday):N/A
    Forward P/E (fye Dec 31, 2016)1:N/A
    PEG Ratio (5 yr expected)1:-7.21
    Price/Sales (ttm):25.61
    Price/Book (mrq):23.06
    Enterprise Value/Revenue (ttm)3:24.28
    Enterprise Value/EBITDA (ttm)6:-363.06
    Financial Highlights 
    Fiscal Year
    Fiscal Year Ends:Dec 31
    Most Recent Quarter (mrq):Mar 31, 2015
    Profit Margin (ttm):-9.82%
    Operating Margin (ttm):-10.50%
    Management Effectiveness
    Return on Assets (ttm):-1.82%
    Return on Equity (ttm):-7.52%
    Income Statement
    Revenue (ttm):248.58M
    Revenue Per Share (ttm):2.10
    Qtrly Revenue Growth (yoy):122.20%
    Gross Profit (ttm):214.16M
    EBITDA (ttm)6:-16.63M
    Net Income Avl to Common (ttm):-24.42M
    Diluted EPS (ttm):-0.21
    Qtrly Earnings Growth (yoy):N/A
    Balance Sheet
    Total Cash (mrq):788.50M
    Total Cash Per Share (mrq):6.59
    Total Debt (mrq):462.27M
    Total Debt/Equity (mrq):167.58
    Current Ratio (mrq):8.33
    Book Value Per Share (mrq):2.31
    Cash Flow Statement
    Operating Cash Flow (ttm):-4.21M
    Levered Free Cash Flow (ttm):-4.18M
    View Financials
    Income Statement - Balance Sheet - Cash Flow

    Trading Information 
    Stock Price History
    52-Week Change3:74.83%
    S&P500 52-Week Change3:8.50%
    52-Week High (Mar 20, 2015)3:77.80
    52-Week Low (Aug 4, 2014)3:29.17
    50-Day Moving Average3:57.42
    200-Day Moving Average3:63.82
    Share Statistics
    Avg Vol (3 month)3:2,328,350
    Avg Vol (10 day)3:1,525,060
    Shares Outstanding5:119.71M
    % Held by Insiders1:0.79%
    % Held by Institutions1:88.80%
    Shares Short (as of Jul 15, 2015)3:13.49M
    Short Ratio (as of Jul 15, 2015)3:4.90
    Short % of Float (as of Jul 15, 2015)3:13.40%
    Shares Short (prior month)3:16.36M
    Dividends & Splits
    Forward Annual Dividend Rate4:N/A
    Forward Annual Dividend Yield4:N/A
    Trailing Annual Dividend Yield3:N/A
    Trailing Annual Dividend Yield3:N/A
    5 Year Average Dividend Yield4:N/A
    Payout Ratio4:N/A
    Dividend Date3:N/A
    Ex-Dividend Date4:N/A
    Last Split Factor (new per old)2:N/A
    Last Split Date3:N/A

    See Key Statistics Help for definitions of terms used.
    Abbreviation Guide: K = Thousands; M = Millions; B = Billions
    mrq = Most Recent Quarter (as of Mar 31, 2015)
    ttm = Trailing Twelve Months (as of Mar 31, 2015)
    yoy = Year Over Year (as of Mar 31, 2015)
    lfy = Last Fiscal Year (as of Dec 31, 2014)
    fye = Fiscal Year Ending
    1 Data provided by Thomson Reuters
    2 Data provided by EDGAR Online
    3 Data derived from multiple sources or calculated by Yahoo! Finance
    4 Data provided by Morningstar, Inc.
    5 Shares outstanding is taken from the most recently filed quarterly or annual report and Market Cap is calculated using shares outstanding.
    6 EBITDA is calculated by Capital IQ using methodology that may differ from that used by a company in its reporting

    Currency in USD.