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    Isis Pharmaceuticals, Inc. (ISIS)

    -NasdaqGS
    63.37 Up 2.22(3.63%) Mar 27, 4:00PM EDT
    |After Hours : 63.43 Up 0.06 (0.09%) Mar 27, 7:33PM EDT
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    Key StatisticsGet Key Statistics for:
    Data provided by Capital IQ, except where noted.
    Valuation Measures 
    Market Cap (intraday)5:7.54B
    Enterprise Value (Mar 29, 2015)3:7.19B
    Trailing P/E (ttm, intraday):N/A
    Forward P/E (fye Dec 31, 2016)1:N/A
    PEG Ratio (5 yr expected)1:-4.08
    Price/Sales (ttm):33.98
    Price/Book (mrq):28.10
    Enterprise Value/Revenue (ttm)3:33.57
    Enterprise Value/EBITDA (ttm)6:-194.19
    Financial Highlights 
    Fiscal Year
    Fiscal Year Ends:Dec 31
    Most Recent Quarter (mrq):Dec 31, 2014
    Profitability
    Profit Margin (ttm):-18.20%
    Operating Margin (ttm):-21.68%
    Management Effectiveness
    Return on Assets (ttm):-3.22%
    Return on Equity (ttm):-12.26%
    Income Statement
    Revenue (ttm):214.16M
    Revenue Per Share (ttm):1.82
    Qtrly Revenue Growth (yoy):100.90%
    Gross Profit (ttm):214.16M
    EBITDA (ttm)6:-37.02M
    Net Income Avl to Common (ttm):-38.98M
    Diluted EPS (ttm):-0.33
    Qtrly Earnings Growth (yoy):N/A
    Balance Sheet
    Total Cash (mrq):810.71M
    Total Cash Per Share (mrq):6.81
    Total Debt (mrq):457.78M
    Total Debt/Equity (mrq):177.59
    Current Ratio (mrq):7.25
    Book Value Per Share (mrq):2.18
    Cash Flow Statement
    Operating Cash Flow (ttm):6.28M
    Levered Free Cash Flow (ttm):14.90M
    View Financials
    Income Statement - Balance Sheet - Cash Flow

    Trading Information 
    Stock Price History
    Beta:1.09
    52-Week Change3:46.66%
    S&P500 52-Week Change3:10.08%
    52-Week High (Mar 20, 2015)3:77.80
    52-Week Low (May 9, 2014)3:22.25
    50-Day Moving Average3:67.30
    200-Day Moving Average3:56.21
    Share Statistics
    Avg Vol (3 month)3:3,298,150
    Avg Vol (10 day)3:4,012,120
    Shares Outstanding5:119.02M
    Float:118.15M
    % Held by Insiders1:0.79%
    % Held by Institutions1:88.80%
    Shares Short (as of Mar 13, 2015)3:16.58M
    Short Ratio (as of Mar 13, 2015)3:6.30
    Short % of Float (as of Mar 13, 2015)3:16.50%
    Shares Short (prior month)3:16.17M
    Dividends & Splits
    Forward Annual Dividend Rate4:N/A
    Forward Annual Dividend Yield4:N/A
    Trailing Annual Dividend Yield3:N/A
    Trailing Annual Dividend Yield3:N/A
    5 Year Average Dividend Yield4:N/A
    Payout Ratio4:N/A
    Dividend Date3:N/A
    Ex-Dividend Date4:N/A
    Last Split Factor (new per old)2:N/A
    Last Split Date3:N/A

    See Key Statistics Help for definitions of terms used.
    Abbreviation Guide: K = Thousands; M = Millions; B = Billions
    mrq = Most Recent Quarter (as of Dec 31, 2014)
    ttm = Trailing Twelve Months (as of Dec 31, 2014)
    yoy = Year Over Year (as of Dec 31, 2014)
    lfy = Last Fiscal Year (as of Dec 31, 2014)
    fye = Fiscal Year Ending
    1 Data provided by Thomson Reuters
    2 Data provided by EDGAR Online
    3 Data derived from multiple sources or calculated by Yahoo! Finance
    4 Data provided by Morningstar, Inc.
    5 Shares outstanding is taken from the most recently filed quarterly or annual report and Market Cap is calculated using shares outstanding.
    6 EBITDA is calculated by Capital IQ using methodology that may differ from that used by a company in its reporting

    Currency in USD.