| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | FMR LLC | 3,279,506 | 8.57 | $5,607,955 | 30-Sep-09 | | DIMENSIONAL FUND ADVISORS LP | 811,846 | 2.12 | $1,388,256 | 30-Sep-09 | | WELLINGTON MANAGEMENT COMPANY, LLP | 5,200,714 | 13.59 | $8,893,220 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 757,416 | 1.98 | $1,295,181 | 30-Sep-09 | | MILLENNIUM MANAGEMENT LLC | 673,775 | 1.76 | $1,152,155 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 517,757 | 1.35 | $885,364 | 30-Sep-09 | | NORDEA INVESTMENT MANAGEMENT BANK DENMARK A/S | 288,000 | .75 | $492,480 | 30-Sep-09 | | NORTHERN TRUST CORPORATION | 282,973 | .74 | $619,710 | 30-Jun-09 | | RENAISSANCE TECHNOLOGIES, LLC | 226,018 | .59 | $386,490 | 30-Sep-09 | | Technical Financial Services LLC | 199,957 | .52 | $341,926 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | FIDELITY GROWTH COMPANY FUND | 2,939,844 | 7.68 | $5,027,133 | 30-Sep-09 | | PRICE (T.ROWE) HEALTH SCIENCES FUND | 800,000 | 2.09 | $1,752,000 | 30-Jun-09 | | H&Q HEALTHCARE INVESTORS | 621,473 | 1.62 | $590,399 | 31-Mar-09 | | DELAWARE GROUP EQUITY FDS III-TREND FUND | 621,300 | 1.62 | $1,360,647 | 30-Jun-09 | | DELAWARE VIP TREND SERIES | 499,400 | 1.31 | $1,093,686 | 30-Jun-09 | | DFA U.S. SMALL CAP VALUE SERIES | 453,034 | 1.18 | $448,503 | 30-Apr-09 | | H&Q LIFE SCIENCES INVESTORS | 430,995 | 1.13 | $409,445 | 31-Mar-09 | | FIDELITY SELECT PORTFOLIOS - BIOTECHNOLOGY | 324,088 | .85 | $554,190 | 30-Sep-09 | | VANGUARD EXTENDED MARKET INDEX FUND | 263,583 | .69 | $577,246 | 30-Jun-09 | | SPARTAN EXTENDED MARKET INDEX FUND | 109,109 | .29 | $186,576 | 30-Sep-09 |
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Value shown is computed using the security's price on the report date given.
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