| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | BAKER BROTHERS ADVISORS, LLC | 4,522,772 | 9.76 | $7,191,207 | 30-Sep-09 | | BVF INC. | 4,190,551 | 9.04 | $6,662,976 | 30-Sep-09 | | WESTFIELD CAPITAL MANAGEMENT COMPANY | 3,891,955 | 8.40 | $6,188,208 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 3,399,746 | 7.34 | $5,405,596 | 30-Sep-09 | | RENAISSANCE TECHNOLOGIES, LLC | 3,016,330 | 6.51 | $4,795,964 | 30-Sep-09 | | WELLINGTON MANAGEMENT COMPANY, LLP | 1,934,042 | 4.17 | $3,075,126 | 30-Sep-09 | | DIMENSIONAL FUND ADVISORS LP | 1,472,513 | 3.18 | $2,341,295 | 30-Sep-09 | | JAY, JEFFREY R. | 1,400,000 | 3.02 | $2,226,000 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 1,202,617 | 2.60 | $1,912,161 | 30-Sep-09 | | STATE STREET CORPORATION | 998,735 | 2.16 | $1,587,988 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | HARBOR SMALL CAP GROWTH FUND | 690,750 | 1.49 | $1,229,535 | 31-Jul-09 | | ISHARES RUSSELL 2000 INDEX FD | 678,613 | 1.46 | $1,078,994 | 30-Sep-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 678,020 | 1.46 | $983,129 | 31-Oct-09 | | FIDELITY SELECT PORTFOLIOS - BIOTECHNOLOGY | 670,094 | 1.45 | $1,065,449 | 30-Sep-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 531,486 | 1.15 | $935,415 | 30-Jun-09 | | VANGUARD EXTENDED MARKET INDEX FUND | 429,022 | .93 | $755,078 | 30-Jun-09 | | CONSULTING GROUP CAPITAL MARKETS-SMALL CAP GROWTH INV | 359,000 | .77 | $588,760 | 31-Aug-09 | | COLLEGE RETIREMENT EQUITIES FUND-STOCK ACCOUNT | 329,859 | .71 | $580,551 | 30-Jun-09 | | NORTHERN SMALL CAP VALUE FUND | 317,323 | .68 | $504,543 | 30-Sep-09 | | DFA U.S. MICRO CAP SERIES | 294,513 | .64 | $662,654 | 30-Apr-09 |
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Value shown is computed using the security's price on the report date given.
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