| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | FMR LLC | 1,845,636 | 9.65 | $44,092,244 | 30-Sep-09 | | MPM Asset Management, LLC | 1,600,469 | 8.37 | $38,235,204 | 30-Sep-09 | | SECTORAL ASSET MANAGEMENT, INC. | 1,281,559 | 6.70 | $30,616,444 | 30-Sep-09 | | HEALTHCOR MANAGEMENT LP | 700,000 | 3.66 | $16,723,000 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 673,592 | 3.52 | $16,092,112 | 30-Sep-09 | | BRIDGER MANAGEMENT LLC | 501,050 | 2.62 | $11,970,084 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 452,376 | 2.37 | $10,807,262 | 30-Sep-09 | | WELLINGTON MANAGEMENT COMPANY, LLP | 399,968 | 2.09 | $9,555,235 | 30-Sep-09 | | Credit Suisse | 2,229,193 | 11.66 | $53,255,420 | 30-Sep-09 | | Credit Suisse/ | 2,229,193 | 11.66 | $53,255,420 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | FIDELITY GROWTH COMPANY FUND | 1,255,000 | 6.56 | $29,981,950 | 30-Sep-09 | | FIDELITY SELECT PORTFOLIOS - BIOTECHNOLOGY | 225,996 | 1.18 | $5,399,044 | 30-Sep-09 | | ISHARES RUSSELL 2000 INDEX FD | 202,670 | 1.06 | $4,841,786 | 30-Sep-09 | | FIDELITY SELECT PORTFOLIOS - HEALTH CARE | 144,500 | .76 | $3,452,105 | 30-Sep-09 | | H&Q LIFE SCIENCES INVESTORS | 135,182 | .71 | $2,177,782 | 31-Mar-09 | | VANGUARD SMALL-CAP INDEX FUND | 130,246 | .68 | $2,400,433 | 30-Jun-09 | | ISHARES RUSSELL 2000 GROWTH INDEX FD | 106,099 | .55 | $2,534,705 | 30-Sep-09 | | VANGUARD SMALL-CAP GROWTH INDEX FUND | 82,624 | .43 | $1,522,760 | 30-Jun-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 78,003 | .41 | $1,437,595 | 30-Jun-09 | | COLLEGE RETIREMENT EQUITIES FUND-STOCK ACCOUNT | 64,607 | .34 | $1,190,707 | 30-Jun-09 |
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*
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Value shown is computed using the security's price on the report date given.
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