| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | KORNITZER CAPITAL MANAGEMENT, INC. | 6,412,750 | 8.61 | $91,189,305 | 30-Sep-09 | | Bank of New York Mellon Corporation | 5,310,542 | 7.13 | $75,515,907 | 30-Sep-09 | | HEALTHCOR MANAGEMENT LP | 5,000,000 | 6.71 | $71,100,000 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 4,189,757 | 5.63 | $59,578,344 | 30-Sep-09 | | ORBIMED ADVISORS LLC. | 3,056,400 | 4.10 | $43,462,008 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 2,574,485 | 3.46 | $36,609,176 | 30-Sep-09 | | DENT (D.F.) & COMPANY, INC. | 2,395,789 | 3.22 | $34,068,119 | 30-Sep-09 | | TIMES SQUARE CAPITAL MANAGEMENT | 1,787,200 | 2.40 | $25,413,984 | 30-Sep-09 | | STATE STREET CORPORATION | 1,463,715 | 1.97 | $20,814,027 | 30-Sep-09 | | GRANAHAN INVESTMENT MANAGEMENT INC. | 1,288,100 | 1.73 | $18,316,782 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | BUFFALO SMALL CAP FUND | 4,898,425 | 6.58 | $51,923,305 | 30-Jun-09 | | VANGUARD EXPLORER FUND, INC. | 1,597,500 | 2.15 | $17,428,725 | 31-Jul-09 | | EATON VANCE WORLDWIDE HEALTH SCIENCES FD | 1,591,900 | 2.14 | $22,636,818 | 30-Sep-09 | | HUSSMAN INVESTMENT TRUST-HUSSMAN STRATEGIC GROWTH FUND | 1,000,000 | 1.34 | $10,600,000 | 30-Jun-09 | | ISHARES S&P SMALLCAP 600 INDEX FD | 864,148 | 1.16 | $13,584,406 | 31-Oct-09 | | ISHARES RUSSELL 2000 INDEX FD | 856,806 | 1.15 | $12,183,781 | 30-Sep-09 | | VANGUARD SMALL-CAP INDEX FUND | 694,570 | .93 | $7,362,442 | 30-Jun-09 | | Aston/Tamro Small Cap Fund | 557,320 | .75 | $6,080,361 | 31-Jul-09 | | H&Q HEALTHCARE INVESTORS | 538,330 | .72 | $4,268,956 | 31-Mar-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 525,637 | .71 | $5,571,752 | 30-Jun-09 |
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Value shown is computed using the security's price on the report date given.
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