| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | BAKER BROTHERS ADVISORS, LLC | 5,832,002 | 5.61 | $42,282,014 | 30-Sep-09 | | ORBIMED ADVISORS LLC. | 4,507,500 | 4.34 | $32,679,375 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 3,925,648 | 3.78 | $28,460,948 | 30-Sep-09 | | CR Intrinsic Investors, LLC | 3,450,000 | 3.32 | $25,012,500 | 30-Sep-09 | | JENNISON ASSOCIATES LLC | 2,936,900 | 2.83 | $21,292,525 | 30-Sep-09 | | COLUMBIA WANGER ASSET MANAGEMENT, L.P. | 2,711,600 | 2.61 | $19,659,100 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 2,539,777 | 2.44 | $18,413,383 | 30-Sep-09 | | FMR LLC | 2,493,090 | 2.40 | $18,074,902 | 30-Sep-09 | | ALGER (FRED) MANAGEMENT INC | 2,109,120 | 2.03 | $15,291,120 | 30-Sep-09 | | AXA | 1,935,216 | 1.86 | $14,030,316 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | JENNISON SECTOR FDS-JENNISON HEALTH SCIENCES FD | 2,412,100 | 2.32 | $17,728,935 | 31-Aug-09 | | EATON VANCE WORLDWIDE HEALTH SCIENCES FD | 1,220,000 | 1.17 | $8,845,000 | 30-Sep-09 | | FIDELITY SELECT PORTFOLIOS - BIOTECHNOLOGY | 1,211,000 | 1.17 | $8,779,750 | 30-Sep-09 | | ISHARES RUSSELL 2000 INDEX FD | 916,640 | .88 | $6,645,640 | 30-Sep-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 772,023 | .74 | $4,361,929 | 31-Oct-09 | | VANGUARD SMALL-CAP INDEX FUND | 761,244 | .73 | $6,310,712 | 30-Jun-09 | | ALGER SMALL CAP GROWTH INSTITUTIONAL PORTFOLIO | 740,550 | .71 | $5,976,238 | 31-Jul-09 | | UBS EUCALYPTUS FUND LLC | 671,100 | .65 | $5,563,419 | 30-Jun-09 | | DFA U.S. MICRO CAP SERIES | 651,602 | .63 | $3,994,320 | 30-Apr-09 | | FIDELITY CONTRAFUND INC | 642,500 | .62 | $4,658,125 | 30-Sep-09 |
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*
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Value shown is computed using the security's price on the report date given.
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