| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | FMR LLC | 1,100,395 | 6.42 | $48,065,253 | 30-Sep-09 | | QVT Financial LP | 1,082,601 | 6.32 | $47,288,011 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 1,019,628 | 5.95 | $44,537,351 | 30-Sep-09 | | PALO ALTO INVESTORS, LLC | 983,004 | 5.74 | $42,937,614 | 30-Sep-09 | | STANDARD LIFE INVESTMENTS (USA) LIMITED | 963,173 | 5.62 | $42,071,396 | 30-Sep-09 | | DSC Advisors, L.P. | 846,900 | 4.94 | $36,992,592 | 30-Sep-09 | | COLUMBIA WANGER ASSET MANAGEMENT, L.P. | 826,900 | 4.83 | $36,118,992 | 30-Sep-09 | | JENNISON ASSOCIATES LLC | 685,200 | 4.00 | $29,929,536 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 670,238 | 3.91 | $29,275,995 | 30-Sep-09 | | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,142,821 | 12.51 | $93,598,421 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | JENNISON SECTOR FDS-JENNISON HEALTH SCIENCES FD | 577,400 | 3.37 | $23,696,496 | 31-Aug-09 | | VARIABLE INSURANCE PRODUCTS FD III-MID-CAP PORTFOLIO | 569,076 | 3.32 | $24,857,239 | 30-Sep-09 | | SMALLCAP WORLD FUND | 400,000 | 2.33 | $21,868,000 | 30-Jun-09 | | ISHARES RUSSELL 2000 INDEX FD | 250,378 | 1.46 | $10,936,511 | 30-Sep-09 | | Fidelity Growth Strategies Fund | 215,581 | 1.26 | $9,416,578 | 30-Sep-09 | | VANGUARD SMALL-CAP INDEX FUND | 207,464 | 1.21 | $11,342,056 | 30-Jun-09 | | AIM SMALL CAP GROWTH FUND | 205,829 | 1.20 | $8,990,610 | 30-Sep-09 | | PIONEER INDEPENDENCE FUND | 172,540 | 1.01 | $9,432,761 | 30-Jun-09 | | FIDELITY ADVISOR MID CAP II FUND | 161,917 | .95 | $7,072,534 | 30-Sep-09 | | JANUS GLOBAL LIFE SCIENCES FUND | 161,742 | .94 | $7,064,890 | 30-Sep-09 |
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Value shown is computed using the security's price on the report date given.
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