| Top Institutional Holders |
|---|
| Holder | Shares | % Out | Value* | Reported |
|---|
| Abingworth, LLP | 8,087,486 | 5.38 | 59,928,271 | Mar 31, 2013 | | Jennison Associates LLC | 7,607,412 | 5.06 | 56,370,922 | Mar 31, 2013 | | FMR, LLC | 5,473,893 | 3.64 | 40,561,547 | Mar 31, 2013 | | Franklin Resources, Inc | 4,879,457 | 3.25 | 36,156,776 | Mar 31, 2013 | | Price (T.Rowe) Associates Inc | 4,120,900 | 2.74 | 30,535,869 | Mar 31, 2013 | | Invesco Ltd. | 3,812,549 | 2.54 | 28,250,988 | Mar 31, 2013 | | Wells Fargo & Company | 2,690,750 | 1.79 | 19,938,457 | Mar 31, 2013 | | Federated Investors, Inc. | 2,400,537 | 1.60 | 17,787,979 | Mar 31, 2013 | | Sectoral Asset Management, Inc. | 1,807,610 | 1.20 | 13,394,390 | Mar 31, 2013 | | Deerfield Management | 1,563,645 | 1.04 | 11,586,609 | Mar 31, 2013 |
|
| Holder | Shares | % Out | Value* | Reported |
|---|
| Prudential Jennison Health Sciences Fd | 3,308,929 | 2.20 | 24,519,163 | Mar 31, 2013 | | Price (T.Rowe) Health Sciences Fund | 2,200,000 | 1.46 | 16,302,000 | Mar 31, 2013 | | Wells Fargo Advantage Small Cap Value Fd | 1,741,700 | 1.16 | 12,905,997 | Mar 31, 2013 | | Prudential Jennison Small Company Fd | 1,180,953 | 0.79 | 8,750,861 | Mar 31, 2013 | | Pioneer Independence Fund | 1,140,000 | 0.76 | 8,447,400 | Mar 31, 2013 | | Price (T.Rowe) New Horizons Fund | 1,144,800 | 0.76 | 8,482,968 | Mar 31, 2013 | | iShares NASDAQ Biotechnology Index Fund | 1,096,007 | 0.73 | 8,121,411 | Mar 31, 2013 | | Franklin Strategic Series-Franklin Small-Mid Cap Growth | 984,200 | 0.65 | 7,292,922 | Mar 31, 2013 | | Invesco Global Health Care Fund | 940,805 | 0.63 | 6,971,365 | Mar 31, 2013 | | Invesco Small Cap Growth Fund | 902,959 | 0.60 | 6,690,926 | Mar 31, 2013 |
|
View Transactions for Insiders & Institutional Holders Value shown is computed using the security's price on the report date given. Currency in USD. |
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