| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | WELLINGTON MANAGEMENT COMPANY, LLP | 3,442,312 | 9.23 | $9,053,280 | 30-Sep-09 | | JAY, JEFFREY R. | 3,132,476 | 8.40 | $8,238,411 | 30-Sep-09 | | JENNISON ASSOCIATES LLC | 2,961,800 | 7.94 | $7,789,534 | 30-Sep-09 | | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,894,500 | 7.76 | $7,612,535 | 30-Sep-09 | | FMR LLC | 1,379,650 | 3.70 | $3,628,479 | 30-Sep-09 | | PRINCIPLED ASSET ADMINISTRATION LLC | 987,100 | 2.65 | $2,596,073 | 30-Sep-09 | | SHAW D.E. & CO., INC. | 856,473 | 2.30 | $2,252,523 | 30-Sep-09 | | FEDERATED INVESTORS, INC. | 781,400 | 2.09 | $2,055,082 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 699,610 | 1.88 | $1,839,974 | 30-Sep-09 | | DRIEHAUS CAPITAL MANAGEMENT, INC. | 631,732 | 1.69 | $1,661,455 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | JENNISON SECTOR FDS-JENNISON HEALTH SCIENCES FD | 2,407,700 | 6.45 | $5,561,787 | 31-Aug-09 | | FIDELITY ADVISOR NEW INSIGHTS FUND | 840,377 | 2.25 | $2,210,191 | 30-Sep-09 | | FEDERATED KAUFMANN SMALL CAP FUND | 576,400 | 1.54 | $1,498,640 | 31-Jul-09 | | FIDELITY SELECT PORTFOLIOS - BIOTECHNOLOGY | 515,918 | 1.38 | $1,356,864 | 30-Sep-09 | | PACIFIC SELECT FUND-HEALTH SCIENCES PORTFOLIO | 496,600 | 1.33 | $923,676 | 30-Jun-09 | | FRANKLIN STRATEGIC SERIES-FRANKLIN BIOTECHNOLOGY DISCOVE | 349,500 | .94 | $919,185 | 30-Sep-09 | | UBS EUCALYPTUS FUND LLC | 260,000 | .70 | $483,600 | 30-Jun-09 | | VANGUARD EXTENDED MARKET INDEX FUND | 246,589 | .66 | $458,655 | 30-Jun-09 | | Advanced Series Tr-AST/Federated Aggressive Growth Port | 188,600 | .51 | $350,796 | 30-Jun-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 144,240 | .39 | $268,286 | 30-Jun-09 |
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Value shown is computed using the security's price on the report date given.
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