| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | BAKER BROTHERS ADVISORS, LLC | 2,884,546 | 7.33 | $2,451,864 | 30-Sep-09 | | DEERFIELD MANAGEMENT | 2,006,147 | 5.09 | $1,705,224 | 30-Sep-09 | | ORBIMED ADVISORS LLC. | 1,842,600 | 4.68 | $1,566,210 | 30-Sep-09 | | BVF INC. | 1,281,521 | 3.25 | $1,089,292 | 30-Sep-09 | | HIGHBRIDGE CAPITAL MANAGEMENT, LLC. | 930,283 | 2.36 | $790,740 | 30-Sep-09 | | STRAUS CAPITAL MANAGEMENT LLC | 583,311 | 1.48 | $495,814 | 30-Sep-09 | | UBS AG | 528,642 | 1.34 | $449,345 | 30-Sep-09 | | BAM Management, LLC | 255,000 | .65 | $216,750 | 30-Sep-09 | | RENAISSANCE TECHNOLOGIES, LLC | 148,525 | .38 | $126,246 | 30-Sep-09 | | Clearbridge Advisors, LLC | 147,075 | .37 | $125,013 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | UBS EUCALYPTUS FUND LLC | 481,500 | 1.22 | $452,610 | 30-Jun-09 | | Legg Mason Partners Aggressive Growth Fd | 135,875 | .35 | $115,493 | 30-Sep-09 | | DFA U.S. SMALL CAP VALUE SERIES | 32,946 | .08 | $16,143 | 30-Apr-09 | | SPARTAN EXTENDED MARKET INDEX FUND | 4,452 | .01 | $3,784 | 30-Sep-09 | | DFA U.S. Core Equity 2 Portfolio | 250 | .00 | $122 | 30-Apr-09 |
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Value shown is computed using the security's price on the report date given.
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