| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | Barclays Global Investors UK Holdings Ltd | 3,094,151 | 6.92 | $14,047,445 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 1,645,499 | 3.68 | $7,470,565 | 30-Sep-09 | | ARNHOLD & S. BLEICHRODER ADVISERS INC. | 1,366,411 | 3.06 | $6,203,505 | 30-Sep-09 | | BVF INC. | 9,092,073 | 20.35 | $41,278,011 | 30-Sep-09 | | Bank of New York Mellon Corporation | 1,319,669 | 2.95 | $5,991,297 | 30-Sep-09 | | DIMENSIONAL FUND ADVISORS LP | 1,301,764 | 2.91 | $5,910,008 | 30-Sep-09 | | PRINCIPLED ASSET ADMINISTRATION LLC | 1,052,802 | 2.36 | $4,779,721 | 30-Sep-09 | | ROTHSCHILD ASSET MANAGEMENT INC | 935,560 | 2.09 | $4,247,442 | 30-Sep-09 | | STATE STREET CORPORATION | 927,499 | 2.08 | $4,210,845 | 30-Sep-09 | | DEERFIELD MANAGEMENT | 735,158 | 1.65 | $3,337,617 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | ISHARES RUSSELL 2000 INDEX FD | 609,319 | 1.36 | $2,766,308 | 30-Sep-09 | | VANGUARD SMALL-CAP INDEX FUND | 504,434 | 1.13 | $3,097,224 | 30-Jun-09 | | FRANKLIN STRATEGIC SERIES-FRANKLIN BIOTECHNOLOGY DISCOVE | 491,209 | 1.10 | $2,230,088 | 30-Sep-09 | | DFA U.S. SMALL CAP VALUE SERIES | 455,318 | 1.02 | $2,026,165 | 30-Apr-09 | | ISHARES S&P SMALLCAP 600 INDEX FD | 364,889 | .82 | $1,222,378 | 31-Oct-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 325,554 | .73 | $1,090,605 | 31-Oct-09 | | COLLEGE RETIREMENT EQUITIES FUND-STOCK ACCOUNT | 317,215 | .71 | $1,947,700 | 30-Jun-09 | | Putnam Global Heath Care Fd | 293,000 | .66 | $1,588,060 | 31-Aug-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 224,047 | .50 | $1,375,648 | 30-Jun-09 | | VANGUARD EXTENDED MARKET INDEX FUND | 221,007 | .49 | $1,356,982 | 30-Jun-09 |
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Value shown is computed using the security's price on the report date given.
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