| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | FMR LLC | 4,758,770 | 9.65 | $11,325,872 | 30-Sep-09 | | DEERFIELD MANAGEMENT | 4,597,846 | 9.32 | $10,942,873 | 30-Sep-09 | | Capital Research Global Investors | 3,615,000 | 7.33 | $8,603,700 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 3,029,945 | 6.14 | $7,211,269 | 30-Sep-09 | | KOPP INVESTMENT ADVISORS. INC. | 3,028,881 | 6.14 | $7,208,736 | 30-Sep-09 | | JANUS CAPITAL MANAGEMENT, LLC | 1,931,753 | 3.92 | $4,597,572 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 1,839,444 | 3.73 | $4,377,876 | 30-Sep-09 | | WELLINGTON MANAGEMENT COMPANY, LLP | 1,716,227 | 3.48 | $4,084,620 | 30-Sep-09 | | PRICE (T.ROWE) ASSOCIATES INC | 1,601,400 | 3.25 | $3,811,332 | 30-Sep-09 | | DIMENSIONAL FUND ADVISORS LP | 1,027,566 | 2.08 | $2,445,607 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | FIDELITY GROWTH COMPANY FUND | 4,758,770 | 9.65 | $11,325,872 | 30-Sep-09 | | SMALLCAP WORLD FUND | 1,920,000 | 3.89 | $6,028,800 | 30-Jun-09 | | PRICE (T.ROWE) NEW HORIZONS FUND | 1,117,700 | 2.27 | $2,660,126 | 30-Sep-09 | | AMERICAN FDS INSURANCE SER-GLOBAL SMALL CAPITALIZATION F | 1,115,000 | 2.26 | $2,653,700 | 30-Sep-09 | | ISHARES RUSSELL 2000 INDEX FD | 708,769 | 1.44 | $1,686,870 | 30-Sep-09 | | NEW ECONOMY FUND (THE) | 580,000 | 1.18 | $1,380,400 | 30-Sep-09 | | VANGUARD SMALL-CAP INDEX FUND | 558,010 | 1.13 | $1,752,151 | 30-Jun-09 | | AIM GLOBAL HEALTH CARE FUND | 541,465 | 1.10 | $1,288,686 | 30-Sep-09 | | JANUS GLOBAL LIFE SCIENCES FUND | 479,198 | .97 | $1,140,491 | 30-Sep-09 | | Columbia Fds Ser Tr I-Columbia Small Cap Growth Fd | 478,700 | .97 | $1,972,244 | 31-Aug-09 |
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Value shown is computed using the security's price on the report date given.
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1.48% Nasdaq 
Major Holders
