| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | HAMBRECHT & QUIST CAPITAL MANAGEMENT, INC. | 800,000 | 4.23 | $976,000 | 30-Sep-09 | | ORBIMED ADVISORS LLC. | 3,610,200 | 19.07 | $4,404,444 | 30-Sep-09 | | WEXFORD CAPITAL LLC | 165,000 | .87 | $201,300 | 30-Sep-09 | | KBC Group NV | 73,227 | .39 | $64,439 | 30-Jun-09 | | GRT CAPITAL PARTNERS, LLC | 17,800 | .09 | $21,716 | 30-Sep-09 | | AMERICAN INTERNATIONAL GROUP, INC | 5,000 | .03 | $6,100 | 30-Sep-09 | | Ameriprise Financial, Inc. | 2,850 | .02 | $3,477 | 30-Sep-09 | | UBS AG | 717 | .00 | $874 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | H&Q HEALTHCARE INVESTORS | 472,000 | 2.49 | $424,800 | 31-Mar-09 | | H&Q LIFE SCIENCES INVESTORS | 328,000 | 1.73 | $295,200 | 31-Mar-09 |
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*
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Value shown is computed using the security's price on the report date given.
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