| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | Southpaw Asset Management LP | 2,683,421 | 8.99 | $3,998,297 | 30-Sep-09 | | DIMENSIONAL FUND ADVISORS LP | 1,050,974 | 3.52 | $1,565,951 | 30-Sep-09 | | RENAISSANCE TECHNOLOGIES, LLC | 1,020,900 | 3.42 | $1,521,141 | 30-Sep-09 | | MILLENNIUM MANAGEMENT LLC | 940,175 | 3.15 | $1,400,860 | 30-Sep-09 | | BVF INC. | 8,819,600 | 29.56 | $13,141,204 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 671,630 | 2.25 | $1,000,728 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 596,587 | 2.00 | $888,914 | 30-Sep-09 | | SHAW D.E. & CO., INC. | 150,935 | .51 | $224,893 | 30-Sep-09 | | LOEB ARBITRAGE MANAGEMENT INC. | 128,074 | .43 | $190,830 | 30-Sep-09 | | NORTHERN TRUST CORPORATION | 59,306 | .20 | $78,283 | 30-Jun-09 |
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| Holder | Shares | % Out | Value* | Reported | | VANGUARD EXTENDED MARKET INDEX FUND | 330,665 | 1.11 | $436,477 | 30-Jun-09 | | DFA U.S. SMALL CAP VALUE SERIES | 300,630 | 1.01 | $369,774 | 30-Apr-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 263,250 | .88 | $347,490 | 30-Jun-09 | | DFA U.S. MICRO CAP SERIES | 262,088 | .88 | $322,368 | 30-Apr-09 | | DFA U.S. SMALL CAP SERIES | 216,991 | .73 | $266,898 | 30-Apr-09 | | ISHARES Russell Micro Cap (TM) Index Fund | 60,661 | .20 | $90,384 | 30-Sep-09 | | KINETICS PORT TR-KINETICS MASTER MEDICAL PORT | 51,000 | .17 | $67,320 | 30-Jun-09 | | VANGUARD INSTITUTIONAL INDEX-INST TOTAL STOCK MARKET IND | 31,139 | .10 | $37,989 | 31-Mar-09 | | SPARTAN EXTENDED MARKET INDEX FUND | 22,946 | .08 | $34,189 | 30-Sep-09 | | DFA U.S. Core Equity 2 Portfolio | 16,279 | .05 | $20,023 | 30-Apr-09 |
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Value shown is computed using the security's price on the report date given.
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