| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | JAY, JEFFREY R. | 1,331,994 | 5.60 | $7,152,807 | 30-Sep-09 | | ORBIMED ADVISORS LLC. | 990,000 | 4.16 | $5,316,300 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 776,694 | 3.26 | $4,170,846 | 30-Sep-09 | | PRICE (T.ROWE) ASSOCIATES INC | 594,200 | 2.50 | $3,190,854 | 30-Sep-09 | | FMR LLC | 2,770,292 | 11.64 | $14,876,468 | 30-Sep-09 | | DIMENSIONAL FUND ADVISORS LP | 457,147 | 1.92 | $2,454,879 | 30-Sep-09 | | WALL STREET ASSOCIATES | 386,900 | 1.63 | $2,077,653 | 30-Sep-09 | | DiamondBack Capital Management | 286,607 | 1.20 | $1,539,079 | 30-Sep-09 | | STATE STREET CORPORATION | 267,612 | 1.12 | $1,437,076 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 220,086 | .92 | $1,181,861 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | FIDELITY SELECT PORTFOLIOS - BIOTECHNOLOGY | 2,190,348 | 9.20 | $11,762,168 | 30-Sep-09 | | PRICE (T.ROWE) HEALTH SCIENCES FUND | 450,000 | 1.89 | $2,322,000 | 30-Jun-09 | | ISHARES RUSSELL 2000 INDEX FD | 222,668 | .94 | $1,195,727 | 30-Sep-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 218,737 | .92 | $914,320 | 31-Oct-09 | | FRANKLIN STRATEGIC SERIES-FRANKLIN BIOTECHNOLOGY DISCOVE | 175,900 | .74 | $944,583 | 30-Sep-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 125,832 | .53 | $649,293 | 30-Jun-09 | | UBS JUNIPER CROSSOVER FUND, LLC | 123,007 | .52 | $634,716 | 30-Jun-09 | | ISHARES RUSSELL 2000 GROWTH INDEX FD | 109,233 | .46 | $586,581 | 30-Sep-09 | | FIDELITY ADVISOR BIOTECHNOLOGY FUND | 100,769 | .42 | $541,129 | 30-Sep-09 | | EVERGREEN HEALTH CARE FUND | 79,499 | .33 | $391,930 | 31-Jul-09 |
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*
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Value shown is computed using the security's price on the report date given.
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