| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | GLG Partners, Inc. | 1,029,076 | 4.72 | $12,565,017 | 30-Sep-09 | | EMERALD ADVISERS | 684,771 | 3.14 | $8,361,053 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 674,218 | 3.09 | $8,232,201 | 30-Sep-09 | | SECTORAL ASSET MANAGEMENT, INC. | 599,115 | 2.75 | $7,315,194 | 30-Sep-09 | | RUDMAN (ERROL M.) | 498,253 | 2.29 | $6,083,669 | 30-Sep-09 | | PALO ALTO INVESTORS, LLC | 453,308 | 2.08 | $5,534,890 | 30-Sep-09 | | Clearbridge Advisors, LLC | 2,243,592 | 10.30 | $27,394,258 | 30-Sep-09 | | MILLENNIUM MANAGEMENT LLC | 350,000 | 1.61 | $4,273,500 | 30-Sep-09 | | DIMENSIONAL FUND ADVISORS LP | 300,247 | 1.38 | $3,666,015 | 30-Sep-09 | | Emerald Mutual Fund Advisers Trust | 298,459 | 1.37 | $3,644,184 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | Legg Mason Partners Aggressive Growth Fd | 1,457,900 | 6.69 | $17,800,959 | 30-Sep-09 | | ING Patrners Inc.-ING/Legg Mason Partners Aggressive Growth | 212,520 | .98 | $1,963,684 | 30-Jun-09 | | Legg Mason Partners VP II-Var Aggressive Growth Port | 208,410 | .96 | $2,161,211 | 31-Jul-09 | | ISHARES RUSSELL 2000 INDEX FD | 201,322 | .92 | $2,458,141 | 30-Sep-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 182,506 | .84 | $2,129,845 | 31-Oct-09 | | Principal Small Cap Growth Fd II | 148,433 | .68 | $1,371,520 | 30-Jun-09 | | Met Investors Ser Tr-Legg Mason Aggressive Growth Port | 145,000 | .67 | $1,339,800 | 30-Jun-09 | | FIDELITY SELECT PORTFOLIOS - BIOTECHNOLOGY | 141,691 | .65 | $1,730,047 | 30-Sep-09 | | ISHARES RUSSELL 2000 GROWTH INDEX FD | 103,023 | .47 | $1,257,910 | 30-Sep-09 | | FORWARD FUND, INC.-GROWTH FUND | 99,968 | .46 | $1,176,623 | 31-Aug-09 |
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Value shown is computed using the security's price on the report date given.
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0.24% Nasdaq 
Major Holders
