| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | Barclays Global Investors UK Holdings Ltd | 6,312,642 | 8.46 | $367,648,270 | 30-Sep-09 | | FMR LLC | 5,936,907 | 7.95 | $345,765,463 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 3,865,747 | 5.18 | $225,141,105 | 30-Sep-09 | | DEUTSCHE BANK AKTIENGESELLSCHAFT | 2,771,699 | 3.71 | $161,423,749 | 30-Sep-09 | | STATE STREET CORPORATION | 2,641,672 | 3.54 | $153,850,977 | 30-Sep-09 | | SHAW D.E. & CO., INC. | 2,299,475 | 3.08 | $133,921,424 | 30-Sep-09 | | HEALTHCOR MANAGEMENT LP | 1,800,000 | 2.41 | $104,832,000 | 30-Sep-09 | | COLUMBIA WANGER ASSET MANAGEMENT, L.P. | 1,670,800 | 2.24 | $97,307,392 | 30-Sep-09 | | WELLINGTON MANAGEMENT COMPANY, LLP | 7,832,542 | 10.49 | $456,167,246 | 30-Sep-09 | | PRICE (T.ROWE) ASSOCIATES INC | 7,579,721 | 10.15 | $441,442,951 | 30-Sep-09 |
|
| Holder | Shares | % Out | Value* | Reported | | PRICE (T.ROWE) MID CAP GROWTH FUND | 2,850,000 | 3.82 | $165,984,000 | 30-Sep-09 | | VANGUARD SPECIALIZED-HEALTH CARE FUND | 2,552,000 | 3.42 | $149,674,800 | 31-Jul-09 | | FIDELITY MID-CAP STOCK FUND | 1,100,000 | 1.47 | $64,064,000 | 30-Sep-09 | | COLUMBIA ACORN FD | 1,000,000 | 1.34 | $56,650,000 | 30-Jun-09 | | Powershares Exhg Traded Fd Tr-Powershares QQQ Tr, Series 1 | 875,822 | 1.17 | $67,867,446 | 30-Sep-08 | | FIDELITY MAGELLAN FUND INC | 778,730 | 1.04 | $45,353,235 | 30-Sep-09 | | VANGUARD MID-CAP INDEX FUND | 778,262 | 1.04 | $44,088,542 | 30-Jun-09 | | VANGUARD 500 INDEX FUND | 707,722 | .95 | $40,092,451 | 30-Jun-09 | | FIDELITY SELECT PORTFOLIOS - BIOTECHNOLOGY | 696,961 | .93 | $40,591,008 | 30-Sep-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 683,440 | .92 | $38,716,876 | 30-Jun-09 |
|
|
*
|
Value shown is computed using the security's price on the report date given.
|
|