| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | WELLINGTON MANAGEMENT COMPANY, LLP | 6,231,058 | 7.60 | $38,881,801 | 30-Sep-09 | | BVF INC. | 5,580,162 | 6.81 | $34,820,210 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 5,331,357 | 6.51 | $33,267,667 | 30-Sep-09 | | HEALTHCOR MANAGEMENT LP | 3,900,000 | 4.76 | $24,336,000 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 3,270,302 | 3.99 | $20,406,684 | 30-Sep-09 | | AXA | 2,997,826 | 3.66 | $18,706,434 | 30-Sep-09 | | MANNING & NAPIER ADVISORS INC | 2,685,970 | 3.28 | $16,760,452 | 30-Sep-09 | | DELAWARE MANAGEMENT BUSINESS TRUST | 2,115,500 | 2.58 | $13,200,720 | 30-Sep-09 | | BB MEDTECH AG | 2,079,000 | 2.54 | $15,841,980 | 30-Jun-09 | | FMR LLC | 9,670,804 | 11.80 | $60,345,816 | 30-Sep-09 |
|
| Holder | Shares | % Out | Value* | Reported | | SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 2,077,018 | 2.53 | $15,826,877 | 30-Jun-09 | | SMALLCAP WORLD FUND | 1,658,000 | 2.02 | $12,633,960 | 30-Jun-09 | | FIDELITY GROWTH COMPANY FUND | 9,289,848 | 11.34 | $57,968,651 | 30-Sep-09 | | VANGUARD EXPLORER FUND, INC. | 1,418,205 | 1.73 | $8,509,230 | 31-Jul-09 | | ISHARES RUSSELL 2000 INDEX FD | 1,202,059 | 1.47 | $7,500,848 | 30-Sep-09 | | Blackrock Funds-Health Sciences Opportunity Portfolio | 1,005,980 | 1.23 | $7,665,567 | 30-Jun-09 | | VANGUARD SMALL-CAP INDEX FUND | 980,404 | 1.20 | $7,470,678 | 30-Jun-09 | | Manning & Napier Maryland Life Sciences Series Fund | 955,000 | 1.17 | $7,277,100 | 30-Jun-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 741,321 | .90 | $5,648,866 | 30-Jun-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 714,065 | .87 | $4,420,062 | 31-Oct-09 |
|
|
*
|
Value shown is computed using the security's price on the report date given.
|
|