| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | SECTORAL ASSET MANAGEMENT, INC. | 4,210,198 | 6.32 | $18,230,157 | 30-Sep-09 | | PIONEER INVESTMENT MANAGEMENT INC. | 3,901,483 | 5.86 | $16,893,421 | 30-Sep-09 | | BRIDGER MANAGEMENT LLC | 2,837,246 | 4.26 | $12,285,275 | 30-Sep-09 | | Allianz Global Investors of America L.P. | 2,575,382 | 3.86 | $11,151,404 | 30-Sep-09 | | PRICE (T.ROWE) ASSOCIATES INC | 2,220,800 | 3.33 | $9,616,064 | 30-Sep-09 | | WELLINGTON MANAGEMENT COMPANY, LLP | 1,969,800 | 2.96 | $8,529,234 | 30-Sep-09 | | AGF FUNDS INC | 1,947,281 | 2.92 | $8,431,726 | 30-Sep-09 | | CR Intrinsic Investors, LLC | 1,850,896 | 2.78 | $8,014,379 | 30-Sep-09 | | GMT CAPITAL CORP | 1,804,700 | 2.71 | $7,814,351 | 30-Sep-09 | | ADAGE CAPITAL PARTNERS GP, L.L.C. | 7,850,000 | 11.78 | $33,990,500 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | PRICE (T.ROWE) NEW HORIZONS FUND | 1,360,600 | 2.04 | $5,891,398 | 30-Sep-09 | | PIONEER INDEPENDENCE FUND | 1,130,380 | 1.70 | $4,205,013 | 30-Jun-09 | | Allianz Fds-OCC Opportunity Fd | 811,824 | 1.22 | $3,628,853 | 31-Aug-09 | | Pioneer Growth Opportunities Fund | 682,110 | 1.02 | $2,537,449 | 30-Jun-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 610,563 | .92 | $2,387,301 | 31-Oct-09 | | FRANKLIN STRATEGIC SERIES-FRANKLIN BIOTECHNOLOGY DISCOVE | 576,828 | .87 | $2,497,665 | 30-Sep-09 | | FIDELITY SELECT PORTFOLIOS - HEALTH CARE | 561,700 | .84 | $2,432,161 | 30-Sep-09 | | Allianz VIP Tr-OCC Opportunity Fd | 460,154 | .69 | $1,711,772 | 30-Jun-09 | | SEI INSTITUTIONAL INVESTMENT TR-SMALL CAP FUND | 345,806 | .52 | $1,435,094 | 31-May-09 | | Pioneer Growth Opportunities VCT Portfolio | 327,156 | .49 | $1,217,020 | 30-Jun-09 |
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Value shown is computed using the security's price on the report date given.
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