| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | Credit Suisse/ | 4,668,350 | 7.66 | $24,695,571 | 30-Sep-09 | | Credit Suisse | 4,668,350 | 7.66 | $24,695,571 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 3,304,002 | 5.42 | $17,478,170 | 30-Sep-09 | | QVT Financial LP | 2,365,887 | 3.88 | $12,515,542 | 30-Sep-09 | | DAFNA Capital Management, LLC | 1,969,631 | 3.23 | $10,419,347 | 30-Sep-09 | | AXA | 1,947,166 | 3.20 | $10,300,508 | 30-Sep-09 | | ORBIMED ADVISORS LLC. | 1,748,000 | 2.87 | $9,246,920 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 1,315,751 | 2.16 | $6,960,322 | 30-Sep-09 | | DEERFIELD MANAGEMENT | 1,315,700 | 2.16 | $6,960,053 | 30-Sep-09 | | WELLINGTON MANAGEMENT COMPANY, LLP | 6,208,111 | 10.19 | $32,840,907 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | HARTFORD GLOBAL HEALTH FUND | 863,703 | 1.42 | $2,556,560 | 31-Jul-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 845,120 | 1.39 | $2,391,689 | 30-Jun-09 | | HARTFORD SMALLCAP GROWTH HLS SERIES | 774,000 | 1.27 | $2,190,420 | 30-Jun-09 | | UBS EUCALYPTUS FUND LLC | 653,600 | 1.07 | $1,849,688 | 30-Jun-09 | | ISHARES RUSSELL 2000 INDEX FD | 643,159 | 1.06 | $3,402,311 | 30-Sep-09 | | GENERAL AMERICAN INVESTORS CO | 529,900 | .87 | $2,803,171 | 30-Sep-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 514,207 | .84 | $1,640,320 | 31-Oct-09 | | HARTFORD GLOBAL HEALTH HLS FUND | 454,000 | .75 | $1,284,820 | 30-Jun-09 | | COLLEGE RETIREMENT EQUITIES FUND-STOCK ACCOUNT | 440,055 | .72 | $1,245,355 | 30-Jun-09 | | ISHARES RUSSELL 2000 GROWTH INDEX FD | 337,020 | .55 | $1,782,835 | 30-Sep-09 |
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*
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Value shown is computed using the security's price on the report date given.
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