| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | VANGUARD GROUP, INC. (THE) | 4,881,030 | 4.21 | $136,620,029 | 30-Sep-09 | | PRIMECAP MANAGEMENT COMPANY | 4,554,500 | 3.93 | $127,480,455 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 4,112,241 | 3.55 | $115,101,625 | 30-Sep-09 | | ORBIMED ADVISORS LLC. | 2,560,000 | 2.21 | $71,654,400 | 30-Sep-09 | | FMR LLC | 17,342,181 | 14.96 | $485,407,646 | 30-Sep-09 | | MILLENNIUM MANAGEMENT LLC | 2,076,657 | 1.79 | $58,125,629 | 30-Sep-09 | | BlackRock Advisors, LLC | 2,007,600 | 1.73 | $56,192,724 | 30-Sep-09 | | Susquehanna International Group, LLP | 2,006,702 | 1.73 | $56,167,588 | 30-Sep-09 | | Visium Asset Management | 2,000,000 | 1.73 | $55,980,000 | 30-Sep-09 | | STATE STREET CORPORATION | 1,891,433 | 1.63 | $52,941,209 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | FIDELITY GROWTH COMPANY FUND | 8,662,381 | 7.47 | $242,460,044 | 30-Sep-09 | | VANGUARD HORIZON FUND-CAPITAL OPPORTUNITY PORTFOLIO | 2,864,600 | 2.47 | $71,615,000 | 30-Jun-09 | | FIDELITY OTC PORTFOLIO | 1,459,800 | 1.26 | $40,859,802 | 30-Sep-09 | | FIDELITY SELECT PORTFOLIOS - BIOTECHNOLOGY | 1,442,700 | 1.24 | $40,381,173 | 30-Sep-09 | | VANGUARD SMALL-CAP INDEX FUND | 1,360,959 | 1.17 | $34,023,975 | 30-Jun-09 | | Fidelity Growth Strategies Fund | 1,034,400 | .89 | $28,952,856 | 30-Sep-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 1,034,333 | .89 | $25,858,325 | 30-Jun-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 1,001,119 | .86 | $25,298,277 | 31-Oct-09 | | LEUTHOLD CORE INVESTMENT FUND | 727,533 | .63 | $20,363,648 | 30-Sep-09 | | Putnam Global Heath Care Fd | 722,070 | .62 | $16,874,775 | 31-Aug-09 |
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Value shown is computed using the security's price on the report date given.
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