| Top Institutional Holders |
|---|
| Holder | Shares | % Out | Value* | Reported |
|---|
| Vanguard Group, Inc. (The) | 8,437,330 | 5.35 | 39,992,944 | Mar 31, 2013 | | Discovery Capital Management, LLC | 5,913,400 | 3.75 | 28,029,516 | Mar 31, 2013 | | State Street Corporation | 5,794,830 | 3.68 | 27,467,494 | Mar 31, 2013 | | Millennium Management LLC | 5,225,059 | 3.32 | 24,766,779 | Mar 31, 2013 | | BlackRock Fund Advisors | 4,987,776 | 3.16 | 23,642,058 | Mar 31, 2013 | | Orbimed Advisors LLC. | 4,346,300 | 2.76 | 20,601,462 | Mar 31, 2013 | | BlackRock Institutional Trust Company, N.A. | 4,310,176 | 2.73 | 20,430,234 | Mar 31, 2013 | | Primecap Management Company | 3,789,800 | 2.40 | 17,963,652 | Mar 31, 2013 | | Putnam Investment Management, LLC | 3,141,237 | 1.99 | 14,889,463 | Mar 31, 2013 | | Shaw D.E. & Co., Inc. | 2,913,591 | 1.85 | 13,810,421 | Mar 31, 2013 |
|
| Holder | Shares | % Out | Value* | Reported |
|---|
| SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 2,979,655 | 1.89 | 14,123,564 | Mar 31, 2013 | | First Trust NYSE Arca Biotechnology Index Fund | 2,696,077 | 1.71 | 14,262,247 | Dec 31, 2012 | | Vanguard Small-Cap Index Fund | 2,565,235 | 1.63 | 13,570,093 | Dec 31, 2012 | | Vanguard Horizon Fund-Capital Opportunity Portfolio | 2,528,900 | 1.60 | 13,377,881 | Dec 31, 2012 | | Fidelity Select Portfolios - Biotechnology | 2,487,677 | 1.58 | 11,791,588 | Mar 31, 2013 | | iShares Russell 2000 Index Fund | 2,470,598 | 1.57 | 11,710,634 | Mar 31, 2013 | | Legg Mason Capital Management Opportunity Trust Fd | 2,200,000 | 1.40 | 10,428,000 | Mar 31, 2013 | | Vanguard Total Stock Market Index Fund | 2,049,042 | 1.30 | 10,839,432 | Dec 31, 2012 | | Vanguard Small-Cap Growth Index Fund | 1,802,040 | 1.14 | 9,532,791 | Dec 31, 2012 | | Putnam Voyager Fund | 1,386,800 | 0.88 | 8,154,384 | Jan 31, 2013 |
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View Transactions for Insiders & Institutional Holders Value shown is computed using the security's price on the report date given. Currency in USD. |
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