| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | WELLINGTON MANAGEMENT COMPANY, LLP | 46,971,815 | 9.96 | $333,969,604 | 30-Sep-09 | | PRICE (T.ROWE) ASSOCIATES INC | 34,070,922 | 7.23 | $242,244,255 | 30-Sep-09 | | WESTFIELD CAPITAL MANAGEMENT COMPANY | 16,367,601 | 3.47 | $116,373,643 | 30-Sep-09 | | FMR LLC | 71,437,304 | 15.15 | $507,919,231 | 30-Sep-09 | | ORBIMED ADVISORS LLC. | 8,788,200 | 1.86 | $62,484,102 | 30-Sep-09 | | BANK OF IRELAND ASSET MANAGEMENT | 6,363,440 | 1.35 | $45,244,058 | 30-Sep-09 | | ORACLE INVESTMENT MANAGEMENT, INC. | 4,902,893 | 1.04 | $34,859,569 | 30-Sep-09 | | UBS GLOBAL ASSET MANAGEMENT (AMERICAS) INC | 3,308,800 | .70 | $23,525,568 | 30-Sep-09 | | LEGAL & GENERAL GROUP PLC | 2,425,719 | .51 | $17,246,862 | 30-Sep-09 | | AVIVA PLC | 2,392,023 | .51 | $17,007,283 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | FIDELITY GROWTH COMPANY FUND | 47,624,212 | 10.10 | $338,608,147 | 30-Sep-09 | | FIDELITY CAPITAL APPRECIATION FUND | 8,625,455 | 1.83 | $61,326,985 | 30-Sep-09 | | VANGUARD SPECIALIZED-HEALTH CARE FUND | 7,721,600 | 1.64 | $60,846,208 | 31-Jul-09 | | PRICE (T.ROWE) MID CAP GROWTH FUND | 7,000,000 | 1.48 | $49,770,000 | 30-Sep-09 | | PRICE (T.ROWE) GROWTH STOCK FUND INC. | 6,667,665 | 1.41 | $47,407,098 | 30-Sep-09 | | EATON VANCE WORLDWIDE HEALTH SCIENCES FD | 3,800,000 | .81 | $27,018,000 | 30-Sep-09 | | FIDELITY OTC PORTFOLIO | 3,572,051 | .76 | $25,397,282 | 30-Sep-09 | | HARTFORD CAPITAL APPRECIATION HLS FUND, INC. | 3,092,000 | .66 | $19,696,040 | 30-Jun-09 | | HARTFORD ADVISERS HLS FUND, INC. | 2,804,000 | .59 | $17,861,480 | 30-Jun-09 | | HARTFORD STOCK HLS FUND, INC. | 2,385,000 | .51 | $15,192,450 | 30-Jun-09 |
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Value shown is computed using the security's price on the report date given.
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0.29% Nasdaq 
Major Holders
