| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | Barclays Global Investors UK Holdings Ltd | 1,574,052 | 6.28 | $27,215,359 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 957,255 | 3.82 | $16,550,938 | 30-Sep-09 | | PUTNAM INVESTMENT MANAGEMENT, LLC | 898,474 | 3.58 | $15,534,615 | 30-Sep-09 | | CHESAPEAKE PARTNERS MANAGEMENT CO INC./MD | 863,309 | 3.44 | $14,926,612 | 30-Sep-09 | | Lusman Capital Management, LLC | 650,000 | 2.59 | $11,238,500 | 30-Sep-09 | | STATE STREET CORPORATION | 607,973 | 2.43 | $10,511,853 | 30-Sep-09 | | Bank of New York Mellon Corporation | 532,509 | 2.12 | $9,207,080 | 30-Sep-09 | | BVF INC. | 3,683,521 | 14.69 | $63,688,078 | 30-Sep-09 | | BAUPOST GROUP, INC,.(THE) LLC | 3,506,875 | 13.99 | $60,633,868 | 30-Sep-09 | | HEALTHCOR MANAGEMENT LP | 500,000 | 1.99 | $8,645,000 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | VANGUARD EXPLORER FUND, INC. | 422,342 | 1.68 | $3,725,056 | 31-Jul-09 | | Powershares Exhg Traded Fd-Dynamic Biotechnology & Genome Po | 373,340 | 1.49 | $3,292,858 | 31-Jul-09 | | ISHARES RUSSELL 2000 INDEX FD | 361,086 | 1.44 | $6,243,176 | 30-Sep-09 | | FIRST EAGLE FUND OF AMERICA, INC. | 312,150 | 1.25 | $2,753,163 | 31-Jul-09 | | VANGUARD SMALL-CAP INDEX FUND | 291,081 | 1.16 | $2,704,142 | 30-Jun-09 | | Goldman Sachs Structured Small Cap Equity Fund | 258,913 | 1.03 | $2,283,612 | 31-Jul-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 216,922 | .87 | $3,715,873 | 31-Oct-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 200,402 | .80 | $1,861,734 | 30-Jun-09 | | Advantage Funds, Inc.-Dreyfus Small Company Value Fund | 191,450 | .76 | $3,310,170 | 30-Sep-09 | | VANGUARD SMALL-CAP GROWTH INDEX FUND | 184,498 | .74 | $1,713,986 | 30-Jun-09 |
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Value shown is computed using the security's price on the report date given.
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