| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | TPG Capital, L.P. | 1,910,273 | 6.68 | $41,758,567 | 30-Sep-09 | | AXA | 1,637,433 | 5.72 | $35,794,285 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 996,581 | 3.48 | $21,785,260 | 30-Sep-09 | | ROYCE & ASSOCIATES, LLC | 966,969 | 3.38 | $21,137,942 | 30-Sep-09 | | ORBIMED ADVISORS LLC. | 854,800 | 2.99 | $18,685,928 | 30-Sep-09 | | JP MORGAN CHASE & COMPANY | 717,731 | 2.51 | $15,689,599 | 30-Sep-09 | | BAKER BROTHERS ADVISORS, LLC | 5,572,425 | 19.48 | $121,813,210 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 538,605 | 1.88 | $11,773,905 | 30-Sep-09 | | Integral Capital Management VII, LLC | 440,000 | 1.54 | $9,618,400 | 30-Sep-09 | | DIMENSIONAL FUND ADVISORS LP | 438,012 | 1.53 | $9,574,942 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | Alliance Bernstein Global Thematic Growth Fund | 716,300 | 2.50 | $12,076,818 | 31-Jul-09 | | EATON VANCE WORLDWIDE HEALTH SCIENCES FD | 663,100 | 2.32 | $14,495,366 | 30-Sep-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 263,256 | .92 | $4,888,663 | 31-Oct-09 | | ISHARES RUSSELL 2000 INDEX FD | 206,893 | .72 | $4,522,680 | 30-Sep-09 | | DFA U.S. MICRO CAP SERIES | 192,364 | .67 | $4,328,190 | 30-Apr-09 | | VANGUARD SMALL-CAP INDEX FUND | 172,829 | .60 | $2,995,126 | 30-Jun-09 | | ALLIANCE BERNSTEIN SMALL CAP GROWTH FUND | 156,600 | .55 | $2,640,276 | 31-Jul-09 | | Transamerica Partners Fd-Small Core Port | 112,680 | .39 | $1,952,744 | 30-Jun-09 | | VANGUARD SMALL-CAP GROWTH INDEX FUND | 109,548 | .38 | $1,898,466 | 30-Jun-09 | | ISHARES RUSSELL 2000 GROWTH INDEX FD | 108,187 | .38 | $2,364,967 | 30-Sep-09 |
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*
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Value shown is computed using the security's price on the report date given.
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