| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | MORGAN STANLEY | 4,731,809 | 9.64 | $196,086,164 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 2,570,168 | 5.24 | $106,507,761 | 30-Sep-09 | | BAMCO INC. | 2,464,541 | 5.02 | $102,130,579 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 1,734,297 | 3.53 | $71,869,267 | 30-Sep-09 | | SECTORAL ASSET MANAGEMENT, INC. | 1,697,828 | 3.46 | $70,357,992 | 30-Sep-09 | | PARNASSUS INVESTMENTS | 1,640,000 | 3.34 | $67,961,600 | 30-Sep-09 | | Perkins Investment Management, LLC | 1,582,437 | 3.22 | $65,576,189 | 30-Sep-09 | | DSM CAPITAL PARTNERS | 1,534,339 | 3.13 | $63,583,008 | 30-Sep-09 | | OSTERWEIS CAPITAL MANAGEMENT, INC. | 1,439,075 | 2.93 | $59,635,268 | 30-Sep-09 | | ValueAct Holdings, L.P. | 1,280,600 | 2.61 | $53,068,064 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | JANUS PERKINS MID CAP VALUE FUND | 1,450,000 | 2.95 | $60,088,000 | 30-Sep-09 | | BARON GROWTH FUND | 1,175,000 | 2.39 | $50,536,750 | 30-Jun-09 | | MORGAN STANLEY INST FD TR-MID CAP GROWTH PORT | 1,031,019 | 2.10 | $44,344,127 | 30-Jun-09 | | CALAMOS GROWTH FUND | 800,000 | 1.63 | $33,152,000 | 30-Sep-09 | | BARON SMALL CAP FUND | 650,000 | 1.32 | $27,956,500 | 30-Jun-09 | | EATON VANCE WORLDWIDE HEALTH SCIENCES FD | 602,300 | 1.23 | $24,959,312 | 30-Sep-09 | | VANGUARD MID-CAP INDEX FUND | 550,732 | 1.12 | $23,686,983 | 30-Jun-09 | | VAN KAMPEN MID CAP GROWTH FUND | 538,412 | 1.10 | $23,157,100 | 30-Jun-09 | | ARTISAN MID-CAP FUND | 512,670 | 1.04 | $22,049,936 | 30-Jun-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 498,590 | 1.02 | $21,444,355 | 30-Jun-09 |
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Value shown is computed using the security's price on the report date given.
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