| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | ORACLE INVESTMENT MANAGEMENT, INC. | 3,095,437 | 8.50 | $39,621,593 | 30-Sep-09 | | BVF INC. | 2,842,200 | 7.80 | $36,380,160 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 1,300,336 | 3.57 | $16,644,300 | 30-Sep-09 | | FMR LLC | 4,436,986 | 12.18 | $56,793,420 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 646,823 | 1.78 | $8,279,334 | 30-Sep-09 | | WESTFIELD CAPITAL MANAGEMENT COMPANY | 478,500 | 1.31 | $6,124,800 | 30-Sep-09 | | DIMENSIONAL FUND ADVISORS LP | 470,204 | 1.29 | $6,018,611 | 30-Sep-09 | | SHAW D.E. & CO., INC. | 434,124 | 1.19 | $5,556,787 | 30-Sep-09 | | STATE STREET CORPORATION | 341,128 | .94 | $4,366,438 | 30-Sep-09 | | NORTHERN TRUST CORPORATION | 252,017 | .69 | $2,326,116 | 30-Jun-09 |
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| Holder | Shares | % Out | Value* | Reported | | FIDELITY OTC PORTFOLIO | 745,704 | 2.05 | $9,545,011 | 30-Sep-09 | | VARIABLE INSURANCE PRODUCTS FD II-CONTRAFUND PORTFOLIO | 707,406 | 1.94 | $9,054,796 | 30-Sep-09 | | FIDELITY BALANCED FUND | 510,632 | 1.40 | $6,536,089 | 30-Sep-09 | | FIDELITY SELECT PORTFOLIOS - BIOTECHNOLOGY | 451,746 | 1.24 | $5,782,348 | 30-Sep-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 334,854 | .92 | $3,006,988 | 31-Oct-09 | | Fidelity Series All Sector Equity Fund | 307,322 | .84 | $3,933,721 | 30-Sep-09 | | FIDELITY CAPITAL APPRECIATION FUND | 282,437 | .78 | $3,615,193 | 30-Sep-09 | | ISHARES RUSSELL 2000 INDEX FD | 281,324 | .77 | $3,600,947 | 30-Sep-09 | | FIDELITY VALUE FUND | 214,529 | .59 | $2,745,971 | 30-Sep-09 | | VANGUARD SMALL-CAP INDEX FUND | 199,952 | .55 | $1,845,556 | 30-Jun-09 |
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*
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Value shown is computed using the security's price on the report date given.
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