| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | Barclays Global Investors UK Holdings Ltd | 3,096,861 | 5.43 | $25,115,542 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 2,270,322 | 3.98 | $18,412,311 | 30-Sep-09 | | BVF INC. | 1,624,672 | 2.85 | $13,176,089 | 30-Sep-09 | | AXA | 1,496,734 | 2.62 | $12,138,512 | 30-Sep-09 | | GRANAHAN INVESTMENT MANAGEMENT INC. | 1,279,870 | 2.24 | $10,379,745 | 30-Sep-09 | | FMR LLC | 8,554,739 | 14.99 | $69,378,933 | 30-Sep-09 | | WELLINGTON MANAGEMENT COMPANY, LLP | 1,112,900 | 1.95 | $9,025,619 | 30-Sep-09 | | STATE STREET CORPORATION | 1,074,788 | 1.88 | $8,716,530 | 30-Sep-09 | | UBS AG | 955,551 | 1.67 | $7,749,518 | 30-Sep-09 | | KINGDON CAPITAL MANAGEMENT LLC | 950,000 | 1.66 | $7,704,500 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | FIDELITY GROWTH COMPANY FUND | 3,891,111 | 6.82 | $31,556,910 | 30-Sep-09 | | FIDELITY CONTRAFUND INC | 1,444,803 | 2.53 | $11,717,352 | 30-Sep-09 | | FIDELITY SMALL CAP STOCK FUND | 1,100,000 | 1.93 | $9,559,000 | 31-Jul-09 | | VANGUARD EXPLORER FUND, INC. | 909,632 | 1.59 | $7,904,702 | 31-Jul-09 | | ISHARES RUSSELL 2000 INDEX FD | 750,915 | 1.32 | $6,089,920 | 30-Sep-09 | | VANGUARD SMALL-CAP INDEX FUND | 648,134 | 1.14 | $5,586,915 | 30-Jun-09 | | VANGUARD VARIABLE INSURANCE FUND-SMALL COMPANY GROWTH | 462,618 | .81 | $3,987,767 | 30-Jun-09 | | Powershares Exhg Traded Fd-Dynamic Biotechnology & Genome Po | 446,297 | .78 | $3,878,320 | 31-Jul-09 | | FIDELITY ADVISOR GROWTH OPPORTUNITIES FUND | 442,900 | .78 | $3,591,919 | 30-Sep-09 | | BRIDGEWAY FDS INC-ULTRA SMALL COMPANY MARKET FD | 423,217 | .74 | $3,648,130 | 30-Jun-09 |
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Value shown is computed using the security's price on the report date given.
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