| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | WELLINGTON MANAGEMENT COMPANY, LLP | 8,530,880 | 7.20 | $57,583,440 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 5,259,498 | 4.44 | $35,501,611 | 30-Sep-09 | | CR Intrinsic Investors, LLC | 4,940,000 | 4.17 | $33,345,000 | 30-Sep-09 | | S.A.C. CAPITAL ADVISORS, LLC | 4,885,000 | 4.12 | $32,973,750 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 4,362,420 | 3.68 | $29,446,335 | 30-Sep-09 | | CITADEL LIMITED PARTNERSHIP | 2,908,220 | 2.45 | $19,630,485 | 30-Sep-09 | | JENNISON ASSOCIATES LLC | 2,783,400 | 2.35 | $18,787,950 | 30-Sep-09 | | MORGAN STANLEY | 2,666,002 | 2.25 | $17,995,513 | 30-Sep-09 | | PRICE (T.ROWE) ASSOCIATES INC | 17,017,910 | 14.36 | $114,870,892 | 30-Sep-09 | | BAKER BROTHERS ADVISORS, LLC | 13,173,417 | 11.11 | $88,920,564 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | PRICE (T.ROWE) NEW HORIZONS FUND | 5,831,300 | 4.92 | $39,361,275 | 30-Sep-09 | | PRICE (T.ROWE) SMALL CAP STOCK FUND | 2,931,200 | 2.47 | $19,785,600 | 30-Sep-09 | | PRICE (T.ROWE) HEALTH SCIENCES FUND | 2,650,000 | 2.24 | $8,718,500 | 30-Jun-09 | | JENNISON SECTOR FDS-JENNISON HEALTH SCIENCES FD | 2,266,800 | 1.91 | $14,938,212 | 31-Aug-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 1,193,734 | 1.01 | $7,031,093 | 31-Oct-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 1,175,891 | .99 | $3,868,681 | 30-Jun-09 | | VANGUARD SMALL-CAP INDEX FUND | 1,062,975 | .90 | $3,497,187 | 30-Jun-09 | | ISHARES RUSSELL 2000 INDEX FD | 1,049,852 | .89 | $7,086,501 | 30-Sep-09 | | HARTFORD GLOBAL HEALTH FUND | 1,004,628 | .85 | $5,224,065 | 31-Jul-09 | | SunAmerica Focused Small Cap Value Fund | 700,000 | .59 | $3,640,000 | 31-Jul-09 |
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*
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Value shown is computed using the security's price on the report date given.
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