| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | BVF INC. | 2,572,908 | 9.82 | $16,029,216 | 30-Sep-09 | | PRICE (T.ROWE) ASSOCIATES INC | 1,279,938 | 4.89 | $7,974,013 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 918,002 | 3.50 | $5,719,152 | 30-Sep-09 | | WELLS FARGO & COMPANY | 857,740 | 3.27 | $5,343,720 | 30-Sep-09 | | WELLINGTON MANAGEMENT COMPANY, LLP | 817,825 | 3.12 | $5,095,049 | 30-Sep-09 | | Bank of New York Mellon Corporation | 659,636 | 2.52 | $4,109,532 | 30-Sep-09 | | DIMENSIONAL FUND ADVISORS LP | 618,081 | 2.36 | $3,850,644 | 30-Sep-09 | | RENAISSANCE TECHNOLOGIES, LLC | 358,975 | 1.37 | $2,236,414 | 30-Sep-09 | | STATE STREET CORPORATION | 284,944 | 1.09 | $1,775,201 | 30-Sep-09 | | BAKER BROTHERS ADVISORS, LLC | 220,973 | .84 | $1,376,661 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | PRICE (T.ROWE) NEW HORIZONS FUND | 699,163 | 2.67 | $4,355,785 | 30-Sep-09 | | Wells Fargo Advantage Small Cap Value Fd | 594,775 | 2.27 | $3,705,448 | 30-Sep-09 | | PRICE (T.ROWE) HEALTH SCIENCES FUND | 375,000 | 1.43 | $2,190,000 | 30-Jun-09 | | ISHARES RUSSELL 2000 INDEX FD | 262,109 | 1.00 | $1,632,939 | 30-Sep-09 | | Jennison Blend Fund | 152,087 | .58 | $947,502 | 30-Sep-09 | | DFA U.S. MICRO CAP SERIES | 148,385 | .57 | $914,051 | 30-Apr-09 | | DFA U.S. SMALL CAP SERIES | 143,104 | .55 | $881,520 | 30-Apr-09 | | VANGUARD EXTENDED MARKET INDEX FUND | 103,074 | .39 | $601,952 | 30-Jun-09 | | COLLEGE RETIREMENT EQUITIES FUND-STOCK ACCOUNT | 98,467 | .38 | $575,047 | 30-Jun-09 | | ISHARES RUSSELL 2000 VALUE INDEX FD | 85,303 | .33 | $531,437 | 30-Sep-09 |
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*
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Value shown is computed using the security's price on the report date given.
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