| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | BVF INC. | 5,992,531 | 9.74 | $5,992,531 | 30-Sep-09 | | RENAISSANCE TECHNOLOGIES, LLC | 1,558,900 | 2.53 | $1,558,900 | 30-Sep-09 | | Visium Asset Management | 1,254,813 | 2.04 | $1,254,813 | 30-Sep-09 | | CAXTON ASSOCIATES, L.L.C. | 9,068,100 | 14.74 | $9,068,100 | 30-Sep-09 | | PERCEPTIVE ADVISORS LLC | 898,527 | 1.46 | $898,527 | 30-Sep-09 | | BAKER BROTHERS ADVISORS, LLC | 620,904 | 1.01 | $620,904 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 396,068 | .64 | $396,068 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 305,901 | .50 | $305,901 | 30-Sep-09 | | CALPERS (CALIFORNIA-PUBLIC EMPLOYEES RETIREMENT SYSTEM) | 133,600 | .22 | $52,104 | 30-Jun-09 | | DIMENSIONAL FUND ADVISORS LP | 102,000 | .17 | $102,000 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | VANGUARD EXTENDED MARKET INDEX FUND | 326,688 | .53 | $127,408 | 30-Jun-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 24,180 | .04 | $9,430 | 30-Jun-09 | | DFA U.S. MICRO CAP SERIES | 12,200 | .02 | $4,148 | 30-Apr-09 | | SPARTAN EXTENDED MARKET INDEX FUND | 8,093 | .01 | $8,093 | 30-Sep-09 | | FIDELITY NASDAQ COMPOSITE INDEX FUND | 1,533 | .00 | $1,533 | 30-Sep-09 | | VANGUARD BALANCED INDEX FUND | 1,400 | .00 | $546 | 30-Jun-09 | | FIDELITY NASDAQ COMPOSITE INDEX TRACKING STOCK | 1,351 | .00 | $1,351 | 30-Sep-09 |
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*
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Value shown is computed using the security's price on the report date given.
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