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Saturday, November 28, 2009, 11:26AM ET - U.S. Markets Closed. Dow  1.48% Nasdaq  1.73%

Isis Pharmaceuticals, Inc. (ISIS)

On Nov 27: 11.00   0.19 (1.70%)

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Major Holders Get Major Holders for:
BREAKDOWN % of Shares Held by All Insider and 5% Owners: 6% % of Shares Held by Institutional & Mutual Fund Owners: 82% % of Float Held by Institutional & Mutual Fund Owners: 87% Number of Institutions Holding Shares: 188 MAJOR DIRECT HOLDERS (FORMS 3 & 4) Holder Shares Reported WENDER JOSEPH H 31,000 3-Jul-08 ECKER DAVID J 0 2-Sep-08 KLEIN JOSEPH III 8,000 11-Aug-08 PARSHALL B LYNNE 1,985 6-Jul-09 BENNETT C FRANK 976 23-Jul-09
TOP INSTITUTIONAL HOLDERS Holder Shares % Out Value* Reported FEDERATED INVESTORS, INC. 7,649,677 7.78 $111,455,793 30-Sep-09 VANGUARD GROUP, INC. (THE) 5,785,105 5.88 $84,288,979 30-Sep-09 Barclays Global Investors UK Holdings Ltd 5,524,563 5.62 $80,492,882 30-Sep-09 STATE STREET CORPORATION 3,205,091 3.26 $46,698,175 30-Sep-09 OPPENHEIMER FUNDS, INC. 3,010,600 3.06 $43,864,442 30-Sep-09 Clearbridge Advisors, LLC 2,255,838 2.29 $32,867,559 30-Sep-09 SECTORAL ASSET MANAGEMENT, INC. 2,000,713 2.03 $29,150,388 30-Sep-09 FMR LLC 14,718,917 14.96 $214,454,620 30-Sep-09 WADDELL & REED FINANCIAL INC. 1,789,550 1.82 $26,073,743 30-Sep-09 PINNACLE ASSOCIATES, LTD. 1,783,261 1.81 $25,982,112 30-Sep-09 TOP MUTUAL FUND HOLDERS Holder Shares % Out Value* Reported FIDELITY GROWTH COMPANY FUND 9,832,981 9.99 $143,266,533 30-Sep-09 FEDERATED KAUFMANN FUND 6,880,757 6.99 $125,780,237 31-Jul-09 OPPENHEIMER GLOBAL OPPORTUNITIES FUND 3,000,000 3.05 $49,500,000 30-Jun-09 VANGUARD EXPLORER FUND, INC. 1,691,749 1.72 $30,925,171 31-Jul-09 FIDELITY OTC PORTFOLIO 1,548,049 1.57 $22,555,073 30-Sep-09 VANGUARD STRATEGIC EQUITY FUND 1,525,802 1.55 $25,175,733 30-Jun-09 ISHARES RUSSELL 2000 INDEX FD 1,368,756 1.39 $19,942,774 30-Sep-09 WADDELL & REED ADVISORS FDS-SCIENCE & TECHNOLOGY FUND 1,150,300 1.17 $18,979,950 30-Jun-09 VANGUARD SMALL-CAP INDEX FUND 1,131,182 1.15 $18,664,503 30-Jun-09 SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF 1,079,311 1.10 $17,808,631 30-Jun-09 View Transactions for Insiders & Institutional Holders * Value shown is computed using the security's price on the report date given.
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