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    Isis Pharmaceuticals, Inc. (ISIS)

    -NasdaqGS
    56.13 Down 1.03(1.80%) Jul 2, 4:00PM EDT
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    Major HoldersGet Major Holders for:
    Breakdown
    % of Shares Held by All Insider and 5% Owners:1%
    % of Shares Held by Institutional & Mutual Fund Owners:89%
    % of Float Held by Institutional & Mutual Fund Owners:90%
    Number of Institutions Holding Shares:270

    Major Direct Holders (Forms 3 & 4)
    HolderSharesReported
    CROOKE STANLEY T14,642Jul 1, 2015
    WENDER JOSEPH H31,665Jul 2, 2015
    BERTHELSEN SPENCER R61,843Jul 2, 2015
    PARSHALL B LYNNE8,143Jul 1, 2015
    BENNETT C FRANK7,316Jul 1, 2015


    Top Institutional Holders
    HolderShares% OutValue*Reported
    ClearBridge Investments, LLC9,586,1578.01610,350,597Mar 31, 2015
    Vanguard Group, Inc. (The)8,013,0266.69510,189,349Mar 31, 2015
    BB Biotech Ag5,729,4264.79364,792,541Mar 31, 2015
    Waddell & Reed Financial Inc.5,450,4004.55347,026,957Mar 31, 2015
    BlackRock Fund Advisors4,594,0993.84292,506,274Mar 31, 2015
    State Street Corporation3,170,8312.65201,886,803Mar 31, 2015
    BlackRock Institutional Trust Company, N.A.3,160,8972.64201,254,305Mar 31, 2015
    FMR, LLC17,546,05014.661,117,156,968Mar 31, 2015
    Pinnacle Associates, Ltd.1,889,0171.58120,273,708Mar 31, 2015
    Franklin Resources, Inc1,729,6581.44110,127,321Mar 31, 2015

    Top Mutual Fund Holders
    HolderShares% OutValue*Reported
    Fidelity Growth Company Fund8,210,1976.86522,743,226Mar 31, 2015
    Ivy Science & Technology Fund3,090,9002.58196,797,596Mar 31, 2015
    Legg Mason Clearbridge Aggressive Growth Fd2,631,0002.20167,515,764Mar 31, 2015
    Fidelity Select Portfolios - Biotechnology2,384,9871.99151,852,117Mar 31, 2015
    Vanguard Small-Cap Index Fund2,156,1911.80137,284,676Mar 31, 2015
    Fidelity Series Growth Company Fund2,115,0851.77134,667,457Mar 31, 2015
    Vanguard Total Stock Market Index Fund2,079,7061.74132,414,876Mar 31, 2015
    iShares Russell 2000 ETF2,000,8631.67127,394,943Mar 31, 2015
    Waddell & Reed Advisors Funds-Science & Technology Fund1,986,9001.66126,505,919Mar 31, 2015
    iShares NASDAQ Biotechnology ETF1,468,4311.2393,494,998Mar 31, 2015

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    Value shown is computed using the security's price on the report date given.

    Currency in USD.