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    Isis Pharmaceuticals, Inc. (ISIS)

    -NasdaqGS
    51.54 Down 0.02(0.04%) Aug 28, 4:00PM EDT
    |After Hours : 51.60 Up 0.06 (0.12%) Aug 28, 5:59PM EDT
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    Major HoldersGet Major Holders for:
    Breakdown
    % of Shares Held by All Insider and 5% Owners:1%
    % of Shares Held by Institutional & Mutual Fund Owners:89%
    % of Float Held by Institutional & Mutual Fund Owners:90%
    Number of Institutions Holding Shares:270

    Major Direct Holders (Forms 3 & 4)
    HolderSharesReported
    CROOKE STANLEY T14,642Jul 6, 2015
    WENDER JOSEPH H31,665Jul 2, 2015
    BERTHELSEN SPENCER R61,843Jul 2, 2015
    PARSHALL B LYNNE8,143Jul 6, 2015
    BENNETT C FRANK7,316Jul 1, 2015


    Top Institutional Holders
    HolderShares% OutValue*Reported
    ClearBridge Investments, LLC9,423,0027.87542,293,755Jun 30, 2015
    Vanguard Group, Inc. (The)8,580,3507.17493,799,133Jun 30, 2015
    BB Biotech Ag5,929,4264.95341,238,460Jun 30, 2015
    Waddell & Reed Financial Inc.5,769,3004.82332,023,209Jun 30, 2015
    BlackRock Institutional Trust Company, N.A.3,015,4472.52173,538,971Jun 30, 2015
    BlackRock Fund Advisors2,617,9632.19150,663,768Jun 30, 2015
    State Street Corporation2,500,8312.09143,922,821Jun 30, 2015
    FMR, LLC17,650,30214.741,015,774,862Jun 30, 2015
    Franklin Resources, Inc1,969,9831.65113,372,519Jun 30, 2015
    Pinnacle Associates, Ltd.1,828,8781.53105,251,927Jun 30, 2015

    Top Mutual Fund Holders
    HolderShares% OutValue*Reported
    Fidelity Growth Company Fund8,556,7207.15492,439,227Jun 30, 2015
    Ivy Science & Technology Fund3,355,5002.80193,109,021Jun 30, 2015
    Legg Mason Clearbridge Aggressive Growth Fd2,618,9822.19150,722,411Jun 30, 2015
    Fidelity Select Portfolios - Biotechnology2,384,9871.99137,255,999Jun 30, 2015
    Fidelity Series Growth Company Fund2,167,3931.81124,733,464Jun 30, 2015
    Vanguard Small-Cap Index Fund2,156,1911.80137,284,676Mar 31, 2015
    Vanguard Total Stock Market Index Fund2,079,7061.74132,414,876Mar 31, 2015
    Waddell & Reed Advisors Funds-Science & Technology Fund2,024,2001.69116,492,707Jun 30, 2015
    iShares NASDAQ Biotechnology ETF1,532,3231.2888,185,187Jun 30, 2015
    Vanguard Small-Cap Growth Index Fund1,394,0521.1688,759,288Mar 31, 2015

    View Transactions for Insiders & Institutional Holders

    Value shown is computed using the security's price on the report date given.

    Currency in USD.