| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | WELLINGTON MANAGEMENT COMPANY, LLP | 6,526,235 | 7.93 | $34,066,946 | 30-Sep-09 | | DEERFIELD MANAGEMENT | 5,521,011 | 6.71 | $28,819,677 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 3,946,089 | 4.79 | $20,598,584 | 30-Sep-09 | | BAKER BROTHERS ADVISORS, LLC | 3,608,190 | 4.38 | $18,834,751 | 30-Sep-09 | | KINGDON CAPITAL MANAGEMENT LLC | 3,000,000 | 3.65 | $15,660,000 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 2,486,154 | 3.02 | $12,977,723 | 30-Sep-09 | | JENNISON ASSOCIATES LLC | 1,900,000 | 2.31 | $9,918,000 | 30-Sep-09 | | JAY, JEFFREY R. | 1,500,000 | 1.82 | $7,830,000 | 30-Sep-09 | | SCHRODER INVESTMENT MANAGEMENT GROUP | 1,449,283 | 1.76 | $7,565,257 | 30-Sep-09 | | TCW GROUP, INC. (THE) | 1,176,899 | 1.43 | $6,143,412 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | JENNISON SECTOR FDS-JENNISON HEALTH SCIENCES FD | 1,456,200 | 1.77 | $8,693,514 | 31-Aug-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 930,092 | 1.13 | $4,157,511 | 31-Oct-09 | | Powershares Exhg Traded Fd-Dynamic Biotechnology & Genome Po | 902,390 | 1.10 | $4,385,615 | 31-Jul-09 | | ISHARES RUSSELL 2000 INDEX FD | 901,273 | 1.10 | $4,704,645 | 30-Sep-09 | | JOHN HANCOCK SMALL CAP EQUITY FUND | 870,733 | 1.06 | $3,892,176 | 31-Oct-09 | | BNY-MELLON SMALL CAP STOCK FUND | 519,300 | .63 | $2,710,746 | 30-Sep-09 | | VANGUARD SMALL-CAP INDEX FUND | 516,906 | .63 | $2,873,997 | 30-Jun-09 | | DFA U.S. MICRO CAP SERIES | 503,708 | .61 | $2,261,648 | 30-Apr-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 476,381 | .58 | $2,648,678 | 30-Jun-09 | | ISHARES RUSSELL 2000 GROWTH INDEX FD | 472,046 | .57 | $2,464,080 | 30-Sep-09 |
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Value shown is computed using the security's price on the report date given.
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