| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | SECTORAL ASSET MANAGEMENT, INC. | 4,613,902 | 9.89 | $73,499,458 | 30-Sep-09 | | SHAW D.E. & CO., INC. | 3,692,651 | 7.91 | $58,823,930 | 30-Sep-09 | | ORBIMED ADVISORS LLC. | 3,131,500 | 6.71 | $49,884,795 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 2,513,954 | 5.39 | $40,047,287 | 30-Sep-09 | | OPPENHEIMER FUNDS, INC. | 2,136,300 | 4.58 | $34,031,259 | 30-Sep-09 | | COLUMBIA WANGER ASSET MANAGEMENT, L.P. | 1,794,500 | 3.85 | $28,586,385 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 1,493,265 | 3.20 | $23,787,711 | 30-Sep-09 | | BAKER BROTHERS ADVISORS, LLC | 1,472,782 | 3.16 | $23,461,417 | 30-Sep-09 | | DEERFIELD MANAGEMENT | 1,464,663 | 3.14 | $23,332,081 | 30-Sep-09 | | FMR LLC | 6,016,017 | 12.89 | $95,835,150 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | FIDELITY GROWTH COMPANY FUND | 4,283,017 | 9.18 | $68,228,460 | 30-Sep-09 | | COLUMBIA ACORN FD | 1,781,707 | 3.82 | $27,081,946 | 30-Jun-09 | | OPPENHEIMER GLOBAL FUND | 1,239,900 | 2.66 | $18,846,480 | 30-Jun-09 | | EATON VANCE WORLDWIDE HEALTH SCIENCES FD | 989,900 | 2.12 | $15,769,107 | 30-Sep-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 615,679 | 1.32 | $7,437,402 | 31-Oct-09 | | ISHARES RUSSELL 2000 INDEX FD | 561,377 | 1.20 | $8,942,735 | 30-Sep-09 | | FIDELITY ADVISOR GROWTH OPPORTUNITIES FUND | 551,900 | 1.18 | $8,791,767 | 30-Sep-09 | | FIDELITY SELECT PORTFOLIOS - BIOTECHNOLOGY | 525,833 | 1.13 | $8,376,519 | 30-Sep-09 | | FIDELITY OTC PORTFOLIO | 478,200 | 1.02 | $7,617,726 | 30-Sep-09 | | VANGUARD SMALL-CAP INDEX FUND | 444,357 | .95 | $6,754,226 | 30-Jun-09 |
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*
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Value shown is computed using the security's price on the report date given.
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