| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | BVF INC. | 11,155,486 | 9.87 | $25,769,172 | 30-Sep-09 | | KNOTT (DAVID M.) | 8,241,473 | 7.29 | $19,037,802 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 7,442,175 | 6.59 | $17,191,424 | 30-Sep-09 | | UBS AG | 5,729,017 | 5.07 | $13,234,029 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 4,529,247 | 4.01 | $10,462,560 | 30-Sep-09 | | PENNANT CAPITAL MANAGEMENT, LLC | 4,315,703 | 3.82 | $9,969,273 | 30-Sep-09 | | SUTTONBROOK CAPITAL MANAGEMENT LP | 2,903,000 | 2.57 | $6,705,930 | 30-Sep-09 | | CHESAPEAKE PARTNERS MANAGEMENT CO INC./MD | 2,484,881 | 2.20 | $5,740,075 | 30-Sep-09 | | WELLINGTON MANAGEMENT COMPANY, LLP | 15,820,737 | 14.00 | $36,545,902 | 30-Sep-09 | | STATE STREET CORPORATION | 2,037,898 | 1.80 | $4,707,544 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | ISHARES RUSSELL 2000 INDEX FD | 1,665,909 | 1.47 | $3,848,249 | 30-Sep-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 1,375,483 | 1.22 | $3,933,881 | 30-Jun-09 | | VANGUARD SMALL-CAP INDEX FUND | 1,238,921 | 1.10 | $3,543,314 | 30-Jun-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 1,119,226 | .99 | $1,902,684 | 31-Oct-09 | | ISHARES RUSSELL 2000 GROWTH INDEX FD | 873,824 | .77 | $2,018,533 | 30-Sep-09 | | HARTFORD GLOBAL HEALTH FUND | 820,300 | .73 | $2,321,449 | 31-Jul-09 | | VANGUARD SMALL-CAP GROWTH INDEX FUND | 783,666 | .69 | $2,241,284 | 30-Jun-09 | | VANGUARD EXTENDED MARKET INDEX FUND | 601,745 | .53 | $1,720,990 | 30-Jun-09 | | FIDELITY SELECT PORTFOLIOS - BIOTECHNOLOGY | 595,700 | .53 | $1,376,067 | 30-Sep-09 | | COLLEGE RETIREMENT EQUITIES FUND-STOCK ACCOUNT | 551,624 | .49 | $1,577,644 | 30-Jun-09 |
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Value shown is computed using the security's price on the report date given.
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