| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | BVF INC. | 11,155,486 | 9.87 | $25,769,172 | 30-Sep-09 | | KNOTT (DAVID M.) | 8,241,473 | 7.29 | $19,037,802 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 7,458,691 | 6.60 | $17,229,576 | 30-Sep-09 | | UBS AG | 5,729,280 | 5.07 | $13,234,636 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 4,533,092 | 4.01 | $10,471,442 | 30-Sep-09 | | PENNANT CAPITAL MANAGEMENT, LLC | 4,315,703 | 3.82 | $9,969,273 | 30-Sep-09 | | SUTTONBROOK CAPITAL MANAGEMENT LP | 2,903,000 | 2.57 | $6,705,930 | 30-Sep-09 | | CHESAPEAKE PARTNERS MANAGEMENT CO INC./MD | 2,484,881 | 2.20 | $5,740,075 | 30-Sep-09 | | WELLINGTON MANAGEMENT COMPANY, LLP | 15,956,492 | 14.12 | $36,859,496 | 30-Sep-09 | | STATE STREET CORPORATION | 2,039,129 | 1.80 | $4,710,387 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | ISHARES RUSSELL 2000 INDEX FD | 1,460,848 | 1.29 | $2,892,479 | 30-Nov-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 1,375,653 | 1.22 | $3,934,367 | 30-Jun-09 | | VANGUARD SMALL-CAP INDEX FUND | 1,238,921 | 1.10 | $3,543,314 | 30-Jun-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 1,110,127 | .98 | $2,198,051 | 30-Nov-09 | | VANGUARD SMALL-CAP GROWTH INDEX FUND | 843,741 | .75 | $1,949,041 | 30-Sep-09 | | ISHARES RUSSELL 2000 GROWTH INDEX FD | 822,608 | .73 | $1,628,763 | 30-Nov-09 | | HARTFORD GLOBAL HEALTH FUND | 820,300 | .73 | $1,894,893 | 30-Sep-09 | | VANGUARD EXTENDED MARKET INDEX FUND | 603,942 | .53 | $1,727,274 | 30-Jun-09 | | COLLEGE RETIREMENT EQUITIES FUND-STOCK ACCOUNT | 551,624 | .49 | $1,577,644 | 30-Jun-09 | | DFA U.S. MICRO CAP SERIES | 537,021 | .48 | $1,519,769 | 31-Jul-09 |
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*
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Value shown is computed using the security's price on the report date given.
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