| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | BAKER BROTHERS ADVISORS, LLC | 2,018,903 | 5.74 | $868,128 | 30-Sep-09 | | Efficient Market Advisors, LLC | 717,820 | 2.04 | $308,662 | 30-Sep-09 | | MPM Asset Management, LLC | 4,814,725 | 13.69 | $2,070,331 | 30-Sep-09 | | Credit Suisse/ | 3,863,422 | 10.99 | $1,661,271 | 30-Sep-09 | | Credit Suisse | 3,863,422 | 10.99 | $1,661,271 | 30-Sep-09 | | WELLINGTON MANAGEMENT COMPANY, LLP | 3,803,464 | 10.82 | $1,635,489 | 30-Sep-09 | | HARRIS (WILLIAM) INVESTORS, INC. | 620,346 | 1.76 | $266,748 | 30-Sep-09 | | DIMENSIONAL FUND ADVISORS LP | 511,614 | 1.46 | $219,994 | 30-Sep-09 | | WELLCOME TRUST LIMITED AS TRUSTEE OF THE WELLCOME TRUST | 474,833 | 1.35 | $204,178 | 30-Sep-09 | | QVT Financial LP | 389,319 | 1.11 | $167,407 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | VANGUARD EXTENDED MARKET INDEX FUND | 348,111 | .99 | $194,942 | 30-Jun-09 | | DFA U.S. SMALL CAP VALUE SERIES | 344,163 | .98 | $165,198 | 31-Jul-09 | | KINETICS PORT TR-KINETICS MASTER MEDICAL PORT | 44,000 | .13 | $18,920 | 30-Sep-09 | | SPARTAN EXTENDED MARKET INDEX FUND | 26,087 | .07 | $10,173 | 31-Oct-09 | | DFA U.S. Core Equity 2 Portfolio | 17,603 | .05 | $8,449 | 31-Jul-09 | | SA FDS INV TR-U.S. SMALL COMPANY FD | 8,450 | .02 | $4,732 | 30-Jun-09 | | DFA U.S. Vector Equity Portfolio | 5,548 | .02 | $1,886 | 30-Apr-09 | | DFA U.S. Core Equity 1 Portfolio | 2,106 | .01 | $1,010 | 31-Jul-09 | | FIDELITY NASDAQ COMPOSITE INDEX TRACKING STOCK | 1,530 | .00 | $596 | 31-Oct-09 | | FIDELITY NASDAQ COMPOSITE INDEX FUND | 1,518 | .00 | $592 | 31-Oct-09 |
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Value shown is computed using the security's price on the report date given.
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