| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | SHAW D.E. & CO., INC. | 5,084,366 | 9.62 | $55,978,869 | 30-Sep-09 | | SECTORAL ASSET MANAGEMENT, INC. | 4,934,175 | 9.33 | $54,325,266 | 30-Sep-09 | | DEERFIELD MANAGEMENT | 4,308,372 | 8.15 | $47,435,175 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 3,244,752 | 6.14 | $35,724,719 | 30-Sep-09 | | ORBIMED ADVISORS LLC. | 3,180,000 | 6.01 | $35,011,800 | 30-Sep-09 | | AXA | 2,158,557 | 4.08 | $23,765,712 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 2,102,245 | 3.98 | $23,145,717 | 30-Sep-09 | | HEALTHCOR MANAGEMENT LP | 1,391,500 | 2.63 | $15,320,415 | 30-Sep-09 | | WELLINGTON MANAGEMENT COMPANY, LLP | 6,582,386 | 12.45 | $72,472,069 | 30-Sep-09 | | PRICE (T.ROWE) ASSOCIATES INC | 5,779,241 | 10.93 | $63,629,443 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | PRICE (T.ROWE) HEALTH SCIENCES FUND | 2,228,100 | 4.21 | $18,693,759 | 30-Jun-09 | | PRICE (T.ROWE) NEW HORIZONS FUND | 1,046,600 | 1.98 | $11,523,066 | 30-Sep-09 | | PRICE (T.ROWE) SMALL CAP STOCK FUND | 947,900 | 1.79 | $10,436,379 | 30-Sep-09 | | EATON VANCE WORLDWIDE HEALTH SCIENCES FD | 858,600 | 1.62 | $9,453,186 | 30-Sep-09 | | ISHARES RUSSELL 2000 INDEX FD | 775,066 | 1.47 | $8,533,476 | 30-Sep-09 | | VANGUARD SMALL-CAP INDEX FUND | 636,779 | 1.20 | $5,342,575 | 30-Jun-09 | | ROYCE MICRO-CAP FUND | 596,400 | 1.13 | $5,003,796 | 30-Jun-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 478,971 | .91 | $4,018,566 | 30-Jun-09 | | VANGUARD SMALL-CAP GROWTH INDEX FUND | 403,589 | .76 | $3,386,111 | 30-Jun-09 | | HARTFORD GLOBAL HEALTH FUND | 385,900 | .73 | $3,129,649 | 31-Jul-09 |
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*
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Value shown is computed using the security's price on the report date given.
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