| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | Barclays Global Investors UK Holdings Ltd | 1,803,226 | 5.38 | $48,939,553 | 30-Sep-09 | | O.S.S. CAPITAL MANAGEMENT, LP | 1,550,000 | 4.63 | $42,067,000 | 30-Sep-09 | | MARXE, AUSTIN W. & GREENHOUSE, DAVID M. | 1,249,584 | 3.73 | $33,913,709 | 30-Sep-09 | | PALO ALTO INVESTORS, LLC | 1,237,551 | 3.69 | $33,587,134 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 1,218,260 | 3.64 | $33,063,576 | 30-Sep-09 | | KINGDON CAPITAL MANAGEMENT LLC | 750,000 | 2.24 | $20,355,000 | 30-Sep-09 | | FMR LLC | 4,350,963 | 12.98 | $118,085,135 | 30-Sep-09 | | QVT Financial LP | 4,074,842 | 12.16 | $110,591,211 | 30-Sep-09 | | STATE STREET CORPORATION | 600,791 | 1.79 | $16,305,467 | 30-Sep-09 | | STANDARD LIFE INVESTMENTS (USA) LIMITED | 585,600 | 1.75 | $15,893,184 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | FIDELITY CONTRAFUND INC | 3,346,892 | 9.99 | $85,412,683 | 31-Oct-09 | | FIDELITY ADVISOR NEW INSIGHTS FUND | 778,000 | 2.32 | $19,854,560 | 31-Oct-09 | | ISHARES RUSSELL 2000 INDEX FD | 383,899 | 1.15 | $9,797,102 | 31-Oct-09 | | VANGUARD SMALL-CAP INDEX FUND | 340,702 | 1.02 | $7,635,131 | 30-Jun-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 296,301 | .88 | $7,561,601 | 31-Oct-09 | | FIDELITY SELECT PORTFOLIOS - BIOTECHNOLOGY | 261,665 | .78 | $6,677,690 | 31-Oct-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 255,467 | .76 | $5,725,015 | 30-Jun-09 | | ISHARES RUSSELL 2000 GROWTH INDEX FD | 216,822 | .65 | $5,533,297 | 31-Oct-09 | | COLLEGE RETIREMENT EQUITIES FUND-STOCK ACCOUNT | 191,232 | .57 | $4,285,509 | 30-Jun-09 | | VANGUARD EXTENDED MARKET INDEX FUND | 169,855 | .51 | $3,806,450 | 30-Jun-09 |
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Value shown is computed using the security's price on the report date given.
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