| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | FEDERATED INVESTORS, INC. | 2,989,516 | 7.62 | $9,118,023 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 2,761,693 | 7.04 | $8,423,163 | 30-Sep-09 | | WELLINGTON MANAGEMENT COMPANY, LLP | 2,209,200 | 5.63 | $6,738,060 | 30-Sep-09 | | DIMENSIONAL FUND ADVISORS LP | 2,117,673 | 5.40 | $6,458,902 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 1,760,706 | 4.49 | $5,370,153 | 30-Sep-09 | | RENAISSANCE TECHNOLOGIES, LLC | 1,181,333 | 3.01 | $3,603,065 | 30-Sep-09 | | AXA | 1,119,091 | 2.85 | $3,413,227 | 30-Sep-09 | | STATE STREET CORPORATION | 865,858 | 2.21 | $2,640,866 | 30-Sep-09 | | BVF INC. | 6,366,547 | 16.24 | $19,417,968 | 30-Sep-09 | | FRANKLIN RESOURCES, INC | 482,000 | 1.23 | $1,470,100 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | FEDERATED KAUFMANN FUND | 3,249,239 | 8.29 | $10,397,564 | 31-Jul-09 | | DFA U.S. SMALL CAP SERIES | 635,986 | 1.62 | $2,098,753 | 30-Apr-09 | | ISHARES RUSSELL 2000 INDEX FD | 571,467 | 1.46 | $1,742,974 | 30-Sep-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 538,013 | 1.37 | $1,737,781 | 30-Jun-09 | | VANGUARD SMALL-CAP INDEX FUND | 469,651 | 1.20 | $1,516,972 | 30-Jun-09 | | FEDERATED KAUFMANN SMALL CAP FUND | 436,900 | 1.11 | $1,398,080 | 31-Jul-09 | | DFA U.S. SMALL CAP VALUE SERIES | 434,736 | 1.11 | $1,434,628 | 30-Apr-09 | | DFA U.S. MICRO CAP SERIES | 386,646 | .99 | $1,275,931 | 30-Apr-09 | | FRANKLIN STRATEGIC SERIES-FRANKLIN BIOTECHNOLOGY DISCOVE | 375,300 | .96 | $1,144,665 | 30-Sep-09 | | ISHARES RUSSELL 2000 GROWTH INDEX FD | 301,189 | .77 | $918,626 | 30-Sep-09 |
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*
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Value shown is computed using the security's price on the report date given.
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