| TOP INSTITUTIONAL HOLDERS |
| Holder | Shares | % Out | Value* | Reported | | WELLINGTON MANAGEMENT COMPANY, LLP | 4,611,029 | 7.42 | $138,192,539 | 30-Sep-09 | | SHAW D.E. & CO., INC. | 4,388,472 | 7.06 | $131,522,505 | 30-Sep-09 | | Barclays Global Investors UK Holdings Ltd | 3,849,723 | 6.20 | $115,376,198 | 30-Sep-09 | | PRICE (T.ROWE) ASSOCIATES INC | 3,356,588 | 5.40 | $100,596,942 | 30-Sep-09 | | LORD ABBETT & CO | 3,332,413 | 5.36 | $99,872,417 | 30-Sep-09 | | SECTORAL ASSET MANAGEMENT, INC. | 3,040,432 | 4.89 | $91,121,747 | 30-Sep-09 | | PALO ALTO INVESTORS, LLC | 2,600,220 | 4.18 | $77,928,593 | 30-Sep-09 | | VANGUARD GROUP, INC. (THE) | 2,419,922 | 3.89 | $72,525,062 | 30-Sep-09 | | JANUS CAPITAL MANAGEMENT, LLC | 1,788,063 | 2.88 | $53,588,248 | 30-Sep-09 | | STATE STREET CORPORATION | 1,754,433 | 2.82 | $52,580,357 | 30-Sep-09 |
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| Holder | Shares | % Out | Value* | Reported | | PRICE (T.ROWE) MID CAP GROWTH FUND | 1,398,000 | 2.25 | $41,898,060 | 30-Sep-09 | | AMERICAN FDS INSURANCE SER-GROWTH FD | 1,000,000 | 1.61 | $29,970,000 | 30-Sep-09 | | LORD ABBETT RESEARCH FUND, SMALL-CAP VALUE SERIES | 949,118 | 1.53 | $30,438,214 | 31-Aug-09 | | ISHARES RUSSELL 2000 INDEX FD | 907,149 | 1.46 | $27,187,255 | 30-Sep-09 | | VANGUARD SPECIALIZED-HEALTH CARE FUND | 807,200 | 1.30 | $28,994,624 | 31-Jul-09 | | ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND | 734,576 | 1.18 | $19,539,721 | 31-Oct-09 | | VANGUARD SMALL-CAP INDEX FUND | 692,018 | 1.11 | $19,556,428 | 30-Jun-09 | | SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 631,140 | 1.02 | $17,836,016 | 30-Jun-09 | | LORD ABBETT FUNDAMENTAL EQUITY FUND | 605,200 | .97 | $21,738,784 | 31-Jul-09 | | VANGUARD TOTAL STOCK MARKET INDEX FUND | 527,061 | .85 | $14,894,743 | 30-Jun-09 |
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Value shown is computed using the security's price on the report date given.
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